ArticleChemical science2018
Unravelling the origins of ice nucleation on organic crystals.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 63 citations in OpenAlex.
- Optical Anisotropy as a Probe of Proton Ordering at Ice Surfaces.Journal of chemical theory and computation · 2026Article
- Thermodynamic Principles of Emerging Cryopreservation Technologies.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Understanding pectin cross-linking in plant cell walls.Communications biology · 2025Article
- Article
- Universality of Hair as a Nucleant: Exploring the Effects of Surface Chemistry and Topography.Crystal growth & design · 2023Article
- Detecting dynamic domains and local fluctuations in complex molecular systems via timelapse neighbors shuffling.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A highly active mineral-based ice nucleating agent supportsJournal of the Royal Society, Interface · 2023Article
- Poly(vinyl alcohol) Molecular Bottlebrushes Nucleate Ice.Biomacromolecules · 2022Article
- Accurate prediction of ice nucleation from room temperature water.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The role of structural order in heterogeneous ice nucleation.Chemical science · 2022Article
- Chemical approaches to cryopreservation.Nature reviews. Chemistry · 2022Review
- The atomistic details of the ice recrystallisation inhibition activity of PVA.Nature communications · 2021Article
- Disclosing crystal nucleation mechanism in lithium disilicate glass through molecular dynamics simulations and free-energy calculations.Scientific reports · 2020Article
- Predicting heterogeneous ice nucleation with a data-driven approach.Nature communications · 2020Article
- Confronting the Challenge of Modeling Cloud and Precipitation Microphysics.Journal of advances in modeling earth systems · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organic molecules such as steroids or amino acids form crystals that can facilitate the formation of ice - arguably the most important phase transition on earth. However, the origin of the ice nucleating ability of organic crystals is still largely unknown. Here, we combine experiments and simulations to unravel the microscopic details of ice formation on cholesterol, a prototypical organic crystal widely used in cryopreservation. We find that cholesterol - which is also a substantial component of cell membranes - is an ice nucleating agent more potent than many inorganic substrates, including the mineral feldspar (one of the most active ice nucleating materials in the atmosphere). Scanning electron microscopy measurements reveal a variety of morphological features on the surfaces of cholesterol crystals: this suggests that the topography of the surface is key to the broad range of ice nucleating activity observed (from -4 to -20 °C). In addition, we show
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.