Evidence map›Paper›PMID 30542546›Full record

ArticleChemical science2018

Multiplex microRNA imaging in living cells using DNA-capped-Au assembled hydrogels.

Xiangdan Meng, Kai Zhang, Wenhao Dai, Yu Cao, Fan Yang, Haifeng Dong, Xueji Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 101 citations in OpenAlex.

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  13. Hybrid hydrogels for biomedical applications.Current opinion in chemical engineering · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiangdan MengBeijing Key Laboratory for Bioengineering and Sensing Technology , Research Center for Bioengineering and Sensing Technology , School of Chemistry and Biological Engineering , University of Science & Technology Beijing , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Kai ZhangBeijing Key Laboratory for Bioengineering and Sensing Technology , Research Center for Bioengineering and Sensing Technology , School of Chemistry and Biological Engineering , University of Science & Technology Beijing , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Wenhao DaiBeijing Key Laboratory for Bioengineering and Sensing Technology , Research Center for Bioengineering and Sensing Technology , School of Chemistry and Biological Engineering , University of Science & Technology Beijing , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Yu CaoBeijing Key Laboratory for Bioengineering and Sensing Technology , Research Center for Bioengineering and Sensing Technology , School of Chemistry and Biological Engineering , University of Science & Technology Beijing , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Fan YangBeijing Key Laboratory for Bioengineering and Sensing Technology , Research Center for Bioengineering and Sensing Technology , School of Chemistry and Biological Engineering , University of Science & Technology Beijing , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Haifeng DongBeijing Key Laboratory for Bioengineering and Sensing Technology , Research Center for Bioengineering and Sensing Technology , School of Chemistry and Biological Engineering , University of Science & Technology Beijing , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.ORCID 0000-0002-6907-6578
Xueji ZhangBeijing Key Laboratory for Bioengineering and Sensing Technology , Research Center for Bioengineering and Sensing Technology , School of Chemistry and Biological Engineering , University of Science & Technology Beijing , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
University of Science and Technology Beijing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasively imaging multiplex microRNAs (miRNAs) in living cells is pivotal to understanding their physiological functions and pathological development due to the key regulatory roles of miRNAs in gene expression. However, developing smart delivery systems with large gene loading capacity, biocompatibility and responsiveness remains a significant challenge. Herein, we successfully incorporated DNA-capped Au nanoparticles (NPs) and their complementary fluorescent DNA sequences into a porous 3D hydrogel network (AuDH), in which hairpin-locked DNAzyme strands and active metal ions were loaded (AuDH/M

Identifiers

PMID30542546
PMCPMC6237120
OpenAlexW2886669926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.