Evidence map›Paper›PMID 30542516›Full record

ArticleOncotarget2018

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.

Jun Nakata, Hiroko Nakajima, Hiromu Hayashibara, Kanako Imafuku, Soyoko Morimoto, Fumihiro Fujiki, Daisuke Motooka, Daisuke Okuzaki, Kana Hasegawa, Naoki Hosen and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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  10. Identification of mouse helper epitopes for WT1-specific CD4Cancer immunology, immunotherapy : CII · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Jun NakataDepartment of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Hiroko NakajimaDepartment of Cancer Immunology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Hiromu HayashibaraDepartment of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Kanako ImafukuDepartment of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Soyoko MorimotoDepartment of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Fumihiro FujikiDepartment of Cancer Immunology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Daisuke MotookaGenome Information Research Center, Research Institute for Microbial Diseases, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Daisuke OkuzakiGenome Information Research Center, Research Institute for Microbial Diseases, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Kana HasegawaDepartment of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Naoki HosenDepartment of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Akihiro TsuboiDepartment of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Yoshihiro OkaDepartment of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Yusuke OjiDepartment of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Haruo SugiyamaDepartment of Cancer Immunology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Osaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In immunotherapy by cancer antigen-derived peptide vaccine, vaccination of cytotoxic T lymphocyte (CTL) peptide alone is common, while it remains unclear whether the addition of helper peptide vaccine to the CTL peptide vaccine is of great advantage for the enhancement of tumor immunity. In the present study, combination vaccine of Wilms' tumor gene 1(WT1) protein-derived CTL and helper peptides induced the strong infiltration of WT1-specific CD8

Indexed as

cancer vaccinehelper vaccineresident memory T cells (TRM)tumor infiltrating lymphocytes (TIL)wilms tumor 1 (WT1)

Identifiers

PMID30542516
PMCPMC6267595
OpenAlexW2901499117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.