Evidence map›Paper›PMID 30542366›Full record

ArticleFrontiers in genetics2018

Redundancy, Feedback, and Robustness in the

Jennifer Lachowiec, G Alex Mason, Karla Schultz, Christine Queitsch

Abstract read
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
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  3. Review
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  6. Article
  7. Article
  8. Review
  9. The variegatedComputational and structural biotechnology journal · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. bioRxiv : the preprint server for biology · 2023
    Article
  16. Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer LachowiecDepartment of Genome Sciences, University of Washington, Seattle, WA, United States.
G Alex MasonDepartment of Genome Sciences, University of Washington, Seattle, WA, United States.
Karla SchultzDepartment of Genome Sciences, University of Washington, Seattle, WA, United States.
Christine QueitschDepartment of Genome Sciences, University of Washington, Seattle, WA, United States.

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
Does organismal robustness explain the missing heritability in complex diseases?DP2OD008371 · OD · UNIVERSITY OF WASHINGTON · PI QUEITSCH, CHRISTINE · 2011 to 2011
$2.3M
NHGRI NIH HHS T32 HG000035NIH HHS DP2 OD008371
6 · The paper itself

Abstract

Organismal development is remarkably robust, tolerating stochastic errors to produce consistent, so-called canalized adult phenotypes. The mechanistic underpinnings of developmental robustness are poorly understood, but recent studies implicate certain features of genetic networks such as functional redundancy, connectivity, and feedback. Here, we examine the

Indexed as

BES1BZR1canalizationdevelopmental robustnesshypocotylplantstochasticityvariance

Identifiers

PMID30542366
PMCPMC6277886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.