ReviewFrontiers in physiology2018
Functional Evolution of Subolesin/Akirin.
Review in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Recent Advances in Vaccine Development Against Poultry Red Mite (Dermanyssus gallinae): A Literature Review on Native and Recombinant Antigens.Acta parasitologica · 2026Review
- High protective efficacy of a recombinant Fer2 vaccine against Dermacentor marginatus infestations.Experimental & applied acarology · 2026Article
- Exploring the Combined Effect of Bm86 and Subolesin Polypeptide Vaccines in Cattle Naturally Infested withVeterinary sciences · 2026Article
- Fourteen anti-tick vaccine targets are variably conserved in cattle fever ticks.Parasites & vectors · 2025Article
- Genomic Insights into Vector-Pathogen Adaptation inPathogens (Basel, Switzerland) · 2025Article
- Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus.NPJ vaccines · 2025Article
- Modelling protein-protein interactions for the design of vaccine chimeric antigens with protective epitopes.PloS one · 2025Article
- Prime-boost vaccination with chimeric antigens adjuvanted in Montanide™ ISA50 V2 confers protection against experimentalFrontiers in immunology · 2025Article
- Overview of Recombinant Tick Vaccines and Perspectives on the Use of Plant-Made Vaccines to Control Ticks of Veterinary Importance.Vaccines · 2024Review
- Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial.NPJ vaccines · 2024Article
- Identification, Expression, Characteristic Analysis, and Immune Function of TwoAnimals : an open access journal from MDPI · 2024Article
- Evolution of tick vaccinology.Parasitology · 2024Review
- Human Tick-Borne Diseases and Advances in Anti-Tick Vaccine Approaches: A Comprehensive Review.Vaccines · 2024Review
- Anti-tick vaccine candidate subolesin is important for blood feeding and innate immune gene expression in soft ticks.PLoS neglected tropical diseases · 2023Article
- AKIR-1 regulates proteasome subcellular function iniScience · 2023Article
- Tick saliva and its role in pathogen transmission.Wiener klinische Wochenschrift · 2023Article
- Low Genetic Polymorphism in the Immunogenic Sequences ofVaccines · 2022Article
- Low NETosis Induced inVaccines · 2022Article
- Article
- Vector microbiota manipulation by host antibodies: the forgotten strategy to develop transmission-blocking vaccines.Parasites & vectors · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.