ArticleFrontiers in cellular neuroscience2018
Anisotropic Panglial Coupling Reflects Tonotopic Organization in the Inferior Colliculus.
Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 9 citations in OpenAlex.
- CaFrontiers in cellular neuroscience · 2023Article
- Approaches to Study Gap Junctional Coupling.Frontiers in cellular neuroscience · 2021Review
- Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness.International journal of molecular sciences · 2020Article
- Article
- A Vector-Based Method to Analyze the Topography of Glial Networks.International journal of molecular sciences · 2019Article
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9 authors at 3 institutions in 1 country.
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Abstract
Astrocytes and oligodendrocytes in different brain regions form panglial networks and the topography of such networks can correlate with neuronal topography and function. Astrocyte-oligodendrocyte networks in the lateral superior olive (LSO)-an auditory brainstem nucleus-were found to be anisotropic with a preferred orientation orthogonally to the tonotopic axis. We hypothesized that such a specialization might be present in other tonotopically organized brainstem nuclei, too. Thus, we analyzed gap junctional coupling in the center of the inferior colliculus (IC)-another nucleus of the auditory brainstem that exhibits tonotopic organization. In acute brainstem slices obtained from mice, IC networks were traced employing whole-cell patch-clamp recordings of single sulforhodamine (SR) 101-identified astrocytes and concomitant intracellular loading of the gap junction-permeable tracer neurobiotin. The majority of dye-coupled networks exhibited an oval topography, which was preferentially oriented orthogonal to the tonotopic axis. Astrocyte processes showed preferentially the same orientation indicating a correlation between astrocyte and network topography. In addition to SR101-positive astrocytes, IC networks contained oligodendrocytes. Using Na
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