Evidence map›Paper›PMID 30542069›Full record

ArticleEmerging microbes & infections2018

Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea.

Chunhui Li, Céline Harmanus, Duolong Zhu, Xiujuan Meng, Shaohui Wang, Juping Duan, Sidi Liu, Chenchao Fu, Pengcheng Zhou, Ruisi Liu and 5 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. The prevalence and molecular epidemiology ofEmerging microbes & infections · 2026
    Observational
  2. Article
  3. Phylogenomic analysis of the collagen-like BclA proteins inApplied and environmental microbiology · 2026
    Article
  4. Article
  5. Phenotypic analysis of variousApplied and environmental microbiology · 2025
    Article
  6. Unique growth and morphology properties of Clade 5bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Phenotypic analysis of variousbioRxiv : the preprint server for biology · 2025
    Article
  9. An Update onToxins · 2022
    Review
  10. Article
  11. Host Immune Responses toFrontiers in microbiology · 2021
    Review
  12. The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Observational
  13. High Prevalence of Genetically RelatedFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chunhui LiDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Céline HarmanusDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Duolong ZhuDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Down Blvd, Tampa, FL, 33612, USA.
Xiujuan MengDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Shaohui WangDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Down Blvd, Tampa, FL, 33612, USA.
Juping DuanDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Sidi LiuDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Chenchao FuDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Pengcheng ZhouDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Ruisi LiuDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Anhua WuDepartment of Infection Control Center of Xiangya Hospital, Central South University, Changsha, 410008, China.
Ed J KuijperDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Wiep Klaas SmitsDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Lei FuDepartment of Infectious Disease of Xiangya Hospital, Central South University, Changsha, 410008, China. fulei92@126.com.
Xingmin SunDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Down Blvd, Tampa, FL, 33612, USA. sun5@health.usf.edu.

Funding

Multivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3M
Signaling pathway of TNF-alpha production and Clostridium difficile infection (CDK01DK092352 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2012 to 2016
$470k
Multivalent Bacillus mucosal vaccines against Clostridium difficile infectionR21AI113470 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2015 to 2016
$438k
The role of tumor progression locus 2 (TPL2) in the pathogenesis of Clostridium difficile infection (CDI)R03DK112004 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2017 to 2018
$154k
NIAID NIH HHS R01 AI132711NIAID NIH HHS R21 AI113470NIDDK NIH HHS K01 DK092352NIDDK NIH HHS R03 DK112004U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI132711
6 · The paper itself

Abstract

The expression of the Clostridium difficile binary toxin CDT is generally observed in the RT027 (ST1) and RT078 (ST11) C. difficile isolates, which are associated with severe C. difficile infection (CDI). However, we recently reported that the non-RT027 and non-RT078 C. difficile strain LC693 (TcdA

Indexed as

ADP Ribose TransferasesAnimalsBacterial ProteinsBiofilmsChinaClostridioides difficileClostridium InfectionsDiarrheaFemaleHospitalizationHumansMiceMice, Inbred BALB CPhenotypeVirulenceactin-specific ADP-ribosyltransferase, ClostridiumADP Ribose TransferasesBacterial Proteins

Identifiers

PMID30542069
PMCPMC6291415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.