SynthesisNature communications2018
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne.
Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris.European journal of human genetics : EJHG · 2024Pooled it
- Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.Nature communications · 2022Pooled it
- Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis.BMC medical genomics · 2021Pooled it
- Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research.Signal transduction and targeted therapy · 2026Review
- Replication of acne susceptibility loci and gene-environment interactions with screen time in Singapore and Malaysia Chinese population.JID innovations : skin science from molecules to population health · 2026Article
- From pixels to pimples.JID innovations : skin science from molecules to population health · 2026Article
- Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome.Cell · 2026Article
- The Polygenic Architecture of Human Diseases Affecting the Hair Follicle.The Journal of investigative dermatology · 2026Review
- Exposome involvement in the development of acne vulgaris.Frontiers in immunology · 2026Review
- Acne tarda: Recommendations for classification, treatment and care as a result of an expert discussion.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026Review
- Genome-wide association meta-regression identifies stem cell lineage orchestration as a key driver of acne risk.medRxiv : the preprint server for health sciences · 2025Article
- The Genetics of Acne.Annals of human genetics · 2025Review
- Article
- Acne Vulgaris and adherence to the mediterranean diet among university students: a case‒control study.Journal of health, population, and nutrition · 2024Article
- Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases.Nature genetics · 2023Article
- Inflammatory loops in the epithelial-immune microenvironment of the skin and skin appendages in chronic inflammatory diseases.Frontiers in immunology · 2023Review
- Genetic Variants Associated with Acne Vulgaris.International journal of general medicine · 2023Review
- The Role of Skin Immune System in Acne.Journal of clinical medicine · 2022Review
- Dynamic changes of genomic methylation profiles at different growth stages in Chinese Tan sheep.Journal of animal science and biotechnology · 2021Article
- Psoriasis and Genetics.Acta dermato-venereologica · 2020Review
Corrections and comments
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Authors and funding
22 authors at 20 institutions in 3 countries.
Funding
Abstract
Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases and 16,144 controls followed by meta-analysis with summary statistics from a previous study, with a total sample size of 26,722. We identify 20 independent association signals at 15 risk loci, 12 of which have not been previously implicated in the disease. Likely causal variants disrupt the coding region of WNT10A and a P63 transcription factor binding site in SEMA4B. Risk alleles at the 1q25 locus are associated with increased expression of LAMC2, in which biallelic loss-of-function mutations cause the blistering skin disease epidermolysis bullosa. These findings indicate that variation affecting the structure and maintenance of the skin, in particular the pilosebaceous unit, is a critical aspect of the genetic predisposition to severe acne.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.