ArticleThe Journal of veterinary medical science2019
Hepatoprotective immune response during Trichinella spiralis infection in mice.
Article in The Journal of veterinary medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Molecular and serological assessment of the therapeutic efficacy of Ivermectin Loaded nanoparticles onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Effect of linex treatment on IFN-γ and IL-4 in mice infected with Trichinella.BMC infectious diseases · 2024Article
- Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice.PLoS pathogens · 2024Article
- Therapeutic effects of myrrh extract and myrrh-based silver nanoparticles onFrontiers in veterinary science · 2024Article
- Immune pathogenesis in pigeons during experimentalFrontiers in veterinary science · 2022Article
- Comparative expression profiles of host circulating miRNAs in response to Trichinella spiralis infection.Veterinary research · 2020Article
- Comparative Proteomic Analysis of Serum from Pigs Experimentally Infected withPathogens (Basel, Switzerland) · 2020Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections with gastrointestinal nematodes provoke immune and inflammatory responses mediated by cytokines released from T-helper type-2 (Th2) cells. Infections with Trichinella species have been reported to differ by the host species. Previously, in rats, we observed acute liver inflammation in response to infection with Trichinella spiralis, and the rat hosts showed a series of biochemical changes characterized by a decrease in serum paraoxonase (PON) 1 activity associated with the down-regulation of hepatic PON1 synthesis. In the present study, we investigated the effect(s) of species differences on the immune response against T. spiralis infection by analyzing serum PON1 activity and the associated inflammatory/anti-inflammatory mediators in mice. There were inconsistent changes in the serum PON1 activity of mice infected with T. spiralis, and these changes were associated with significant increases in the serum levels of interleukin (IL)-2, IL-4, IL-10, IL-12 (p70), granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor α during the enteric phase of the infection, while the levels of IL-5 and interferon γ were significantly increased throughout the entire experimental period. Moreover, T. spiralis infection in mice was associated with little inflammatory cell infiltration in hepatic tissues. Given the zoonotic prevalence of T. spiralis, further mechanistic research in this area is warranted.
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