Synaptojanin regulates Hedgehog signalling by modulating phosphatidylinositol 4-phosphate levels.

Shital Sarah Ahaley

Abstract read

In one paragraph

Article in Journal of biosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 92% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Characterization of a PIP Binding Site in the N-Terminal Domain of V-ATPase a4 and Its Role in Plasma Membrane Association.International journal of molecular sciences · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Shital Sarah AhaleyBiology Department, Indian Institute of Science Education and Research, Pune 411 008, India, shitalahaley@iiserpune.ac.in.

Indian Institute of Science Education and Research Pune · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Hedgehog (Hh) signalling, Hh ligand concentration gradient is effectively translated into a spatially distinct transcriptional program to give precisely controlled context dependent developmental outcomes. In the absence of Hh, the receptor Patched (Ptc) inhibits the signal transducer Smoothened (Smo) by maintaining low phosphatidylinositol 4-phosphate (PI(4)P) levels. Binding of Hh to its receptor Ptc promotes PI(4)P production, which in turn activates Smo. Using wingdiscs of

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsGene Expression RegulationGenes, ReporterGenotypeGreen Fluorescent ProteinsHedgehog ProteinsNerve Tissue ProteinsPhenotypePhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesReceptors, Cell SurfaceSignal TransductionSmoothened ReceptorTranscription Factorsdpp protein, DrosophilaDrosophila ProteinsGAL4 protein, DrosophilaGreen Fluorescent ProteinsHedgehog Proteinshh protein, DrosophilaNerve Tissue Proteinsphosphatidylinositol 4-phosphatePhosphatidylinositol PhosphatesPhosphoric Monoester Hydrolasesptc protein, DrosophilaReceptors, Cell SurfaceSmoothened Receptorsmo protein, DrosophilasynaptojaninTranscription Factors

Identifiers

PMID30541947

OpenAlexW2890404140

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.