Evidence map›Paper›PMID 30541922›Full record

ArticleThe Journal of biological chemistry2019

Accessibility of substituted cysteines in TM2 and TM10 transmembrane segments in the

Sita Nirupama Nishtala, Avish Arora, Jorge Reyes, Myles H Akabas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Sita Nirupama NishtalaFrom the Departments of Physiology and Biophysics.
Avish AroraFrom the Departments of Physiology and Biophysics.
Jorge ReyesFrom the Departments of Physiology and Biophysics.
Myles H AkabasFrom the Departments of Physiology and Biophysics, myles.akabas@einstein.yu.edu.ORCID 0000-0001-8781-7846
Albert Einstein College of Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Inhibitors of Purine Import into Plasmodium falciparum Kill Malaria ParasitesR01AI116665 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AKABAS, MYLES H. · 2015 to 2019
$3.5M
NIAID NIH HHS R01 AI116665NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

Infection with

Indexed as

Amino Acid SubstitutionAntimalarialsBinding SitesBiological TransportCell Membrane PermeabilityCysteineDrug DesignNucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport ProteinsPlasmodium falciparumProtozoan ProteinsPurinesSolubilityWaterAntimalarialsCysteineENT1 protein, Plasmodium falciparumNucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport ProteinsProtozoan ProteinsPurinesWateradenosineantimalarial drugmalariamembrane transportnucleoside/nucleotide transportpurinesubstituted cysteine accessibility method (SCAM)sulfhydrylwater accessibility

Identifiers

PMID30541922
PMCPMC6369291
OpenAlexW2903906639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.