Evidence map›Paper›PMID 30541912›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma.

Xujiao Zhou, Rong Zhang, Shenghai Zhang, Jihong Wu, Xinghuai Sun

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 72 citations in OpenAlex.

  1. Trial
  2. Review
  3. Metallothionein and neurodegenerative diseases.Neural regeneration research · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. The role of RGC degeneration in the pathogenesis of glaucoma.International journal of biological sciences · 2025
    Review
  17. Frontiers in cellular neuroscience · 2025
    Article
  18. The potential role of amino acids in myopia: inspiration from metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Xujiao ZhouEye Institute, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Rong ZhangEye Institute, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Shenghai ZhangShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200032, China.
Jihong WuEye Institute, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China, jihongwu@fudan.edu.cn.
Xinghuai SunEye Institute, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNEye & ENT Hospital of Fudan University · CNFudan University · CNState Key Laboratory of Medical Neurobiology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) receptor agonists are neuroprotective in CNS injury models. However, the neuroprotective functional implications and synaptic mechanism of 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT), a serotonin receptor (5-HT1A) agonist, in an adult male Wistar rat model of chronic glaucoma model remain unknown. We found that ocular hypertension decreased 5-HT1A receptor expression in rat retinas because the number of retinal ganglion cells (RGCs) was significantly reduced in rats with induced ocular hypertension relative to that in control retinas and 8-OH-DPAT enhanced the RGC viability. The protective effects of 8-OH-DPAT were blocked by intravitreal administration of the selective 5-HT1A antagonist WAY-100635 or the selective GABA

Indexed as

8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsBucladesineCyclic AMPCyclic AMP-Dependent Protein KinasesEye Proteinsgamma-Aminobutyric AcidGlaucomaIsoquinolinesMaleOcular HypertensionPhosphorylationPiperazinesPresynaptic TerminalsProtein Processing, Post-TranslationalPyridines8-Hydroxy-2-(di-n-propylamino)tetralinBucladesineCyclic AMPCyclic AMP-Dependent Protein KinasesEye Proteinsgamma-Aminobutyric AcidIsoquinolinesN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamidePiperazinesPyridinesReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSulfonamides5-HT1A receptorGABA releaseglaucomaneuroprotectionprotein kinase A

Identifiers

PMID30541912
PMCPMC6381261
OpenAlexW2905293453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.