ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Inhibition of Nigrostriatal Dopamine Release by Striatal GABA
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- 5-HT4 Receptor Ligand RS67333 Modulates Striatal Acetylcholine and Dopamine Release via the Inhibition of Acetylcholinesterase.ACS chemical neuroscience · 2026Article
- Optogenetic Inhibition of Striatal Parvalbuminergic Interneurons Unmasks Impaired GABA and Adenosine Signaling in DYT1 Knock-In Mice.International journal of molecular sciences · 2026Article
- Local Regulation of Striatal Dopamine Release Shifts from Predominantly Cholinergic in Mice to GABAergic in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Regulation of Dopamine Release by Tonic Activity Patterns in the Striatal Brain Slice.ACS chemical neuroscience · 2025Article
- Dopamine-Glutamate and Dopamine-GABA Co-release.Advances in neurobiology · 2025Review
- Sex and estradiol effects in the rodent dorsal striatum.The European journal of neuroscience · 2024Review
- Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.Nature communications · 2024Article
- Effects of Acute Haloperidol Treatment on Dopaminergic Markers, GADNeurochemical research · 2024Article
- Review
- Article
- Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy.Molecular psychiatry · 2024Article
- GLUT-1DS resistant to ketogenic diet: from clinical feature to in silico analysis. An exemplificative case report with a literature review.Neurogenetics · 2024Review
- Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions?Current opinion in neurobiology · 2024Review
- GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABACell reports · 2024Article
- Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets.Substance abuse and rehabilitation · 2024Review
- Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice.NPJ Parkinson's disease · 2023Article
- Alterations in neurotransmitter co-release in Parkinson's disease.Experimental neurology · 2023Review
- PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.Experimental & molecular medicine · 2023Article
- Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning.Nature neuroscience · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Nigrostriatal dopamine (DA) is critical to action selection and learning. Axonal DA release is locally influenced by striatal neurotransmitters. Striatal neurons are principally GABAergic projection neurons and interneurons, and a small minority of other neurons are cholinergic interneurons (ChIs). ChIs strongly gate striatal DA release via nicotinic receptors (nAChRs) identified on DA axons. Striatal GABA is thought to modulate DA, but GABA receptors have not been documented conclusively on DA axons. However, ChIs express GABA receptors and are therefore candidates for potential mediators of GABA regulation of DA. We addressed whether striatal GABA and its receptors can modulate DA release directly, independently from ChI regulation, by detecting DA in striatal slices from male mice using fast-scan cyclic voltammetry in the absence of nAChR activation. DA release evoked by single electrical pulses in the presence of the nAChR antagonist dihydro-β-erythroidine was reduced by GABA or agonists of GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.