Evidence map›Paper›PMID 30541851›Full record

ArticleJournal of virology2019

Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques.

Maria Dennis, Joshua Eudailey, Justin Pollara, Arthur S McMillan, Kenneth D Cronin, Pooja T Saha, Alan D Curtis, Michael G Hudgens, Genevieve G Fouda, Guido Ferrari and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024
    Review
  4. Frontiers in immunology · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Maria DennisDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Joshua EudaileyDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Justin PollaraDepartment of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Arthur S McMillanDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Kenneth D CroninDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Pooja T SahaDepartment of Biostatistics, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Alan D CurtisDepartment of Microbiology and Immunology and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Michael G HudgensDepartment of Biostatistics, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Genevieve G FoudaDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Guido FerrariDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Munir AlamDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Koen K A Van RompayCalifornia National Primate Research Center, University of California at Davis, Davis, California, USA.ORCID 0000-0002-7375-1337
Kristina De ParisDepartment of Microbiology and Immunology and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sallie PermarDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA sallie.permar@duke.edu sxshen@duke.edu.
Xiaoying ShenDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA sallie.permar@duke.edu sxshen@duke.edu.ORCID 0000-0002-8387-3952
Duke Medical Center · USUniversity of North Carolina at Chapel Hill · USDuke University · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Project 2: RNA vaccination in early life to induce potent and broad HIV Env-specific antibody responsesP01AI117915 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE PARIS, KRISTINA, PERMAR, SALLIE R. · 2015 to 2024
$21.2M
Combined Hepatitis B and HIV-1 envelope vaccination to augment T cell help via linked recognition of unrelated antigensK01OD024877 · OD · DUKE UNIVERSITY · PI POLLARA, JUSTIN JOSEPH · 2017 to 2019
$1.0M
NIAID NIH HHS P01 AI117915NIAID NIH HHS P30 AI050410NIH HHS K01 OD024877NIH HHS P51 OD011107
6 · The paper itself

Abstract

Prevention of mother-to-child transmission (MTCT) is an indispensable component in combatting the global AIDS epidemic. A combination of passive broadly neutralizing antibody (bnAb) infusion and active vaccination promises to provide protection of infants against MTCT from birth through the breastfeeding period and could prime the immune system for lifelong immunity. In this study, we investigate the impact of a single infusion of CD4 binding site (CD4bs) bnAb administered at birth on

Indexed as

AIDS VaccinesAnimalsAntibodies, NeutralizingAntibody FormationEpitopesHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV InfectionsInfectious Disease Transmission, VerticalMacaca mulattaVaccinationVaccinia virusAIDS VaccinesAntibodies, NeutralizingEpitopesHIV AntibodiesHIV Envelope Protein gp120AIDS vaccineantibodybroadly neutralizing antibodyHIVinfantnonhuman primatepassive immunizationpediatric vaccine

Identifiers

PMID30541851
PMCPMC6384077
OpenAlexW2905068088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.