Evidence map›Paper›PMID 30541842›Full record

ArticleJournal of virology2019

A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies.

Ina Fetzer, Meredith E Davis-Gardner, Matthew R Gardner, Barnett Alfant, Jesse A Weber, Neha R Prasad, Amber S Zhou, Michael Farzan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. In vivo evolution of env in SHIV-AD8Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ina FetzerDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Meredith E Davis-GardnerDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Matthew R GardnerDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Barnett AlfantDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Jesse A WeberDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Neha R PrasadDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Amber S ZhouDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Michael FarzanDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA mfarzan@scripps.edu.
Scripps Research Institute · US

Funding

Cell and Gene Therapy for HIV CureUM1AI126623 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JEROME, KEITH R, KIEM, HANS-PETER · 2016 to 2020
$24.2M
Therapeutic Use of an Enhanced Form of CD4-IgR37AI091476 · NIAID · UNIVERSITY OF FLORIDA · PI FARZAN, MICHAEL R. · 2016 to 2025
$9.2M
Optimizing eCD4-Ig for eradication and a functional cureR01AI129868 · NIAID · UNIVERSITY OF FLORIDA · PI FARZAN, MICHAEL R. · 2017 to 2021
$5.2M
An AAV Approach to Treating HIVF32AI122980 · NIAID · SCRIPPS FLORIDA · PI GARDNER, MATTHEW RYAN · 2016 to 2017
$116k
NIAID NIH HHS F32 AI122980NIAID NIH HHS R01 AI129868NIAID NIH HHS R37 AI091476NIAID NIH HHS UM1 AI126623
6 · The paper itself

Abstract

Broadly neutralizing antibodies (bNAbs) target five major epitopes on the HIV-1 envelope glycoprotein (Env). The most potent bNAbs have median half-maximal inhibitory concentration (IC

Indexed as

Antibodies, NeutralizingAntibodies, ViralCD4 AntigensCell LineEpitopesHEK293 CellsHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHumansNeutralization TestsPeptide FragmentsPeptidomimeticsAntibodies, NeutralizingAntibodies, ViralCD4 AntigensEpitopesHIV AntibodiesHIV Envelope Protein gp120HIV envelope protein gp120 (305-321)Peptide FragmentsPeptidomimeticsantibodyCCR5envelope glycoproteinhuman immunodeficiency virustyrosine sulfationV3-glycan

Identifiers

PMID30541842
PMCPMC6384058
OpenAlexW2903666162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.