Evidence map›Paper›PMID 30541832›Full record

ArticleJournal of virology2019

Constraints of Viral RNA Synthesis on Codon Usage of Negative-Strand RNA Virus.

Ryan H Gumpper, Weike Li, Ming Luo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

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  12. Viral NNature communications · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan H Gumpper *Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Weike Li *Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Ming LuoDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA mluo@gsu.edu.
Georgia State University · US

Funding

Mechanism of Paramyxovirus ReplicationR01AI106307 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HE, BIAO, LUO, MING · 2013 to 2016
$2.3M
NIAID NIH HHS R01 AI106307
6 · The paper itself

Abstract

Negative-strand RNA viruses (NSVs) include some of the most pathogenic human viruses known. NSVs completely rely on the host cell for protein translation, but their codon usage bias is often different from that of the host. This discrepancy may have originated from the unique mechanism of NSV RNA synthesis in that the genomic RNA sequestered in the nucleocapsid serves as the template. The stability of the genomic RNA in the nucleocapsid appears to regulate its accessibility to the viral RNA polymerase, thus placing constraints on codon usage to balance viral RNA synthesis. By

Indexed as

AnimalsBase SequenceCell LineCodonCricetinaeGenome, ViralNucleocapsid ProteinsProtein BiosynthesisRNA, ViralSequence Analysis, RNAVesicular stomatitis Indiana virusVirus ReplicationCodonNucleocapsid ProteinsRNA, Viralnucleocapsidsequestered genomeviral polymerase

Identifiers

PMID30541832
PMCPMC6384081
OpenAlexW2904274181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.