Evidence map›Paper›PMID 30541770›Full record

ArticleDisease models & mechanisms2018

Collagen COL22A1 maintains vascular stability and mutations in

Quynh V Ton, Daniel Leino, Sarah A Mowery, Nina O Bredemeier, Pascal J Lafontant, Allison Lubert, Suman Gurung, Janice L Farlow, Tatiana M Foroud, Joseph Broderick and 1 more

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Targeting collagen to optimize cancer immunotherapy.Experimental hematology & oncology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. AreInternational journal of environmental research and public health · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Quynh V TonDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0001-5426-0658
Daniel LeinoDivision of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Sarah A MoweryDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Nina O BredemeierDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Pascal J LafontantDepartment of Biology, DePauw University, Greencastle, IN 46135, USA.
Allison LubertDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Suman GurungDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Janice L FarlowDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Joseph BroderickDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Saulius SumanasDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA saulius.sumanas@cchmc.org.ORCID 0000-0002-8605-6122
Cincinnati Children's Hospital Medical Center · USIndiana University School of MedicineDePauw University · USUniversity of Cincinnati · US

Funding

THE ROLE OF COLLAGEN COL22A1 IN INTRACRANIAL ANEURYSMS AND VASCULAR STABILITYR01HL134815 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SUMANAS, SAULIUS · 2017 to 2020
$1.8M
Endocardial Contribution to the Vascularization of the Zebrafish Heart during Development and RegenerationR15HD084262 · NICHD · DE PAUW UNIVERSITY · PI LAFONTANT, PASCAL J · 2015 to 2015
$287k
Validation of aneurysm associated genes in a zebrafish modelF32HL124889 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TON, QUYNH · 2014 to 2017
$161k
NHLBI NIH HHS F32 HL124889NHLBI NIH HHS R01 HL134815NICHD NIH HHS R15 HD084262
6 · The paper itself

Abstract

Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing approach to generate a loss-of-function mutant in zebrafish

Indexed as

AnimalsBase SequenceBlood VesselsCollagenEmbryo, NonmammalianEndoplasmic Reticulum StressEndothelium, VascularFibroblastsGastrulationGene DeletionHemorrhageHomozygoteHumansIntracranial AneurysmMatrix Metalloproteinase 9MiceCOL22A1 protein, humanCol22a1 protein, zebrafishCollagenMatrix Metalloproteinase 9RNA, MessengerZebrafish ProteinsCollagenIntracranial aneurysmsVascular integrityZebrafish

Identifiers

PMID30541770
PMCPMC6307901
OpenAlexW2904619841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.