ArticleCancer imaging : the official publication of the International Cancer Imaging Society2018
IDEAL-IQ in an oncologic population: meeting the challenge of concomitant liver fat and liver iron.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Radiomics nomograms based on R2* mapping and clinical biomarkers for staging of liver fibrosis in patients with chronic hepatitis B: a single-center retrospective study.European radiology · 2023Trial
- Reproducibility of ROI methods and reliability of conventional versus chemical shift-encoded MRI for hepatic fat and iron quantification.Abdominal radiology (New York) · 2026Article
- Prediction of late-pregnancy pelvic floor dysfunction: a nomogram model based on proton density fat fraction and synthetic magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Correlation between liver fat fraction measured by MRI IDEAL-IQ sequence and ALT, GGT, and AST in colorectal cancer patients after chemotherapy.BMC gastroenterology · 2026Article
- Article
- Magnetic resonance imaging for noninvasive assessment of renal fat deposition and hypoxia in diabetic kidney disease.BMC medical imaging · 2025Article
- Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) for evaluation of early bone mass changes in ageing osteoporosis patients.Magnetic resonance letters · 2025Article
- Kidney R2* Mapping for Noninvasive Evaluation of Iron Overload in Paroxysmal Nocturnal Hemoglobinuria.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Ultra-Processed Food Consumption and Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD): A Longitudinal and Sustainable Analysis.Nutrients · 2025Article
- Quantitative assessment of renal steatosis in patients with type 2 diabetes mellitus using the iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence imaging: repeatability and clinical implications.Quantitative imaging in medicine and surgery · 2024Article
- Quantitative assessment of rotator cuff injuries using synthetic MRI and IDEAL-IQ imaging techniques.Heliyon · 2024Article
- Diffusion-tensor magnetic resonance imaging as a non-invasive assessment of extracellular matrix remodeling in lumbar paravertebral muscles of rats with sarcopenia.BMC musculoskeletal disorders · 2024Article
- Quantitative susceptibility mapping for detection of kidney stones, hemorrhage differentiation, and cyst classification in ADPKD.Abdominal radiology (New York) · 2024Article
- IDEAL-IQ combined with intravoxel incoherent motion diffusion-weighted imaging for quantitative diagnosis of osteoporosis.BMC medical imaging · 2024Article
- IDEAL-IQ measurement can distinguish dysplastic nodule from early hepatocellular carcinoma: a case-control study.Quantitative imaging in medicine and surgery · 2024Article
- Relationship between Femoral Proximal Bone Quality Assessment by MRI IDEAL-IQ Sequence and Body Mass Index in Elderly Men.Tomography (Ann Arbor, Mich.) · 2024Article
- Article
- Fat fraction and R2 * values of various liver masses: Initial experience with 6-point Dixon method on a 3T MRI system.European journal of radiology open · 2023Article
- Hepatic MR imaging using IDEAL-IQ sequence: Will Gd-EOB-DTPA interfere with reproductivity of fat fraction quantification?World journal of clinical cases · 2023Article
- Plasma Fatty Acid Composition, Oxidative and Inflammatory Status, and Adherence to the Mediterranean Diet of Patients with Non-Alcoholic Fatty Liver Disease.Antioxidants (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundCancer patients often have a history of chemotherapy, putting them at increased risk of liver toxicity and pancytopenia, leading to elevated liver fat and elevated liver iron respectively. T1-in-and-out-of-phase, the conventional MR technique for liver fat assessment, fails to detect elevated liver fat in the presence of concomitantly elevated liver iron. IDEAL-IQ is a more recently introduced MR fat quantification method that corrects for multiple confounding factors, including elevated liver iron.
methodsThis retrospective study was approved by the institutional review board with a waiver for informed consent. We reviewed the MRI studies of 50 cancer patients (30 males, 20 females, 50-78 years old) whose exams included (1) T1-in-and-out-of-phase, (2) IDEAL-IQ, and (3) T2* mapping. Two readers independently assessed fat and iron content from conventional and IDEAL-IQ MR methods. Intraclass correlation coefficient (ICC) was estimated to evaluate agreement between conventional MRI and IDEAL-IQ in measuring R2* level (a surrogate for iron level), and in measuring fat level. Agreement between the two readers was also assessed. Wilcoxon signed rank test was employed to compare iron level and fat fraction between conventional MRI and IDEAL-IQ.
resultsTwenty percent of patients had both elevated liver iron and moderate/severe hepatic steatosis. Across all patients, there was high agreement between readers for IDEAL-IQ fat fraction (ICC = 0.957) and IDEAL R2* (ICC = 0.971) measurements, but lower agreement for conventional fat fraction measurements (ICC = 0.626). The fat fractions calculated with IOP were statistically significantly different from those calculated with IDEAL-IQ (reader 1: p < 0.001, reader 2: p < 0.001).
conclusionFat measurements using IDEAL-IQ and IOP diverged in patients with concomitantly elevated liver fat and liver iron. Given prior work validating IDEAL-IQ, these diverging measurements indicate that IOP is inadequate to screen for hepatic steatosis in our cancer population.
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