Evidence map›Paper›PMID 30541585›Full record

Trial reportJournal of neuroengineering and rehabilitation2018

Evaluation of the Keeogo exoskeleton for assisting ambulatory activities in people with multiple sclerosis: an open-label, randomized, cross-over trial.

Chris A McGibbon, Andrew Sexton, Arun Jayaraman, Susan Deems-Dluhy, Pearl Gryfe, Alison Novak, Tilak Dutta, Eric Fabara, Catherine Adans-Dester, Paolo Bonato

3 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02904382 withheldnot on this map

[Trial of device that is not approved or cleared by the U.S. FDA]

Typen_aSponsor[Redacted]
NCT04653896 nacompletednot on this mapstarted 2021, after this paper: background citation

Design Improvements and Evaluation of a Knee Stress-Relief Powered Exoskeleton for Veterans With Knee Osteoarthritis

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2021 to 2025Enrolled32ConditionsKnee OsteoarthritisArmsKeeogo
NCT06070987 nacompletednot on this mapstarted 2023, after this paper: background citation

To Estimate the Efficacy of Botulinum Toxin A Injection Combing With Exoskeleton Robotic Assisted Gait Training in Stroke Patients With Spastic Stiff Knee Gait: Motor Function Performance and Neurophysiological Evaluation

TypeinterventionalSponsorChang Gung Memorial HospitalRan2023 to 2025Enrolled30ConditionsSpastic Gait, SpasticArmsBoNT-A injections, RF BoNT-A injection in first period and robot therapy, RF BoNT-A injection in second period and robot therapy
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Chris A McGibbonInstitute of Biomedical Engineering, University of New Brunswick, Fredericton, NB, Canada. cmcgibb@unb.ca.ORCID 0000-0001-7849-7895
Andrew SextonInstitute of Biomedical Engineering, University of New Brunswick, Fredericton, NB, Canada.
Arun JayaramanShirley Ryan AbilityLab / Rehabilitation Institute of Chicago, Chicago, IL, USA.
Susan Deems-DluhyShirley Ryan AbilityLab / Rehabilitation Institute of Chicago, Chicago, IL, USA.
Pearl GryfeAssistive Technology Clinic, Toronto, ON, Canada.
Alison NovakToronto Rehabilitation Institute, Toronto, ON, Canada.
Tilak DuttaToronto Rehabilitation Institute, Toronto, ON, Canada.
Eric FabaraDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USA.
Catherine Adans-DesterDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USA.
Paolo BonatoDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USA.
Harvard University · USShirley Ryan AbilityLab · USUniversity of New Brunswick · CAToronto Rehabilitation Institute · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough physical activity and exercise is known to benefit people with multiple sclerosis (MS), the ability of these individuals to participate in such interventions is difficult due to the mobility impairments caused by the disease. Keeogo is a lower-extremity powered exoskeleton that may be a potential solution for enabling people with MS to benefit from physical activity and exercise.

methodsAn open-label, randomized, cross-over trial was used to examine the immediate performance effects when using the device, and the potential benefits of using the device in a home setting for 2 weeks. Clinical performance tests with and without the device included the 6 min walk test, timed up and go test and the 10-step stair test (up and down). An activity monitor was also used to measure physical activity at home, and a patient-reported questionnaire was used to determine the amount and extent of home use. Generalized linear models were used to test for trial effects, and correlation analysis used to examine relationships between trial effects and usage.

resultsTwenty-nine patients with MS participated. All measures showed small decrements in performance while wearing the device compared to not wearing the device. However, significant improvements in unassisted (Rehab effect) performance were found after using the device at home for 2 weeks, compared to 2 weeks at home without the device, and participants improved their ability to use the device over the trial period (Training effect). Rehab and Training effects were related to the self-reported extent that participants used Keeogo at home.

conclusionsKeeogo appears to deliver an exercise-mediated benefit to individuals with MS that improved their unassisted gait endurance and stair climbing ability. Keeogo might be a useful tool for delivering physical activity interventions to individuals with mobility impairment due to MS.

trial registrationClinicalTrials.gov : NCT02904382 . Registered 19 September 2016 - Retrospectively registered.

Indexed as

Exercise TherapyExoskeleton DeviceAdultCross-Over StudiesFemaleGait Disorders, NeurologicHumansMaleMiddle AgedMultiple SclerosisPostural BalanceRetrospective StudiesYoung AdultAmbulation aidHome mobility aidMobilityNeurological disorderPowered orthosis

Identifiers

PMID30541585
PMCPMC6291941
OpenAlexW2904623626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.