Evidence map›Paper›PMID 30541572›Full record

Trial reportJournal of the International Society of Sports Nutrition2018

Efficacy of a nootropic spearmint extract on reactive agility: a randomized, double-blind, placebo-controlled, parallel trial.

Paul H Falcone, Aaron C Tribby, Roxanne M Vogel, Jordan M Joy, Jordan R Moon, Chantelle A Slayton, Micah M Henigman, Joanne A Lasrado, Brandon J Lewis, Brenda A Fonseca and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02518165 (A Randomized, Double-Blind, Placebo-Controlled, Parallel Trial to Assess the Effects of A Proprietary Spearmint Extract on Cognitive Performance, Mood, and Sleep in Men and Women), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02518165 nacompletednot on this map

A Randomized, Double-Blind, Placebo-Controlled, Parallel Trial to Assess the Effects of A Proprietary Spearmint Extract on Cognitive Performance, Mood, and Sleep in Men and Women

TypeinterventionalSponsorKemin Foods LCRan2015 to 2017Enrolled142ConditionsMood, Cognitive Performance, SleepArmsProprietary spearmint extract, Placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Paul H FalconeMusclePharm Sports Science Institute, Denver, CO, USA. paul.h.falcone@gmail.com.ORCID http://orcid.org/0000-0002-7548-1385
Aaron C TribbyMusclePharm Sports Science Institute, Denver, CO, USA.
Roxanne M VogelMusclePharm Sports Science Institute, Denver, CO, USA.
Jordan M JoyMusclePharm Sports Science Institute, Denver, CO, USA.
Jordan R MoonMusclePharm Sports Science Institute, Denver, CO, USA.
Chantelle A SlaytonMusclePharm Sports Science Institute, Denver, CO, USA.
Micah M HenigmanMusclePharm Sports Science Institute, Denver, CO, USA.
Joanne A LasradoKemin Foods L.C, Des Moines, IA, USA.
Brandon J LewisKemin Foods L.C, Des Moines, IA, USA.
Brenda A FonsecaKemin Foods L.C, Des Moines, IA, USA.
Kristin M NiemanKemin Foods L.C, Des Moines, IA, USA.
Kelli A HerrlingerKemin Foods L.C, Des Moines, IA, USA.
Kemin (Belgium) · BEMusclePharm Sports Science Institute (United States) · USApplied Spectral Imaging (United States) · USEnergy Science Laboratories (United States) · USMercy Hospital Springfield · USTexas Woman's University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProprietary spearmint extract (PSE) containing a minimum 14.5% rosmarinic acid and 24% total phenolic content, has evinced positive effects on cognition in individuals aged 50-70 with memory impairment after chronic supplementation. To address the growing interest in connecting mental and physical performance, the present study examined whether the nootropic effects of PSE translate into changes in reactive agility following daily supplementation with PSE.

methodsUtilizing a randomized, double-blind, placebo-controlled, parallel design, healthy, recreationally-active men and women (n = 142) received 900 mg of PSE or placebo (PLA) daily for 90 days. Reactive agility, our primary outcome, was determined by measuring the number of hits and average reaction time (ART) on a Makoto Arena II, a 360

resultsAn overall treatment effect (p = 0.019) was evident for increased hits with PSE on the stationary test with footplates, with between group differences at Day 30 (PSE vs. PLA: 28.96 ± 2.08 vs. 28.09 ± 1.92 hits; p = 0.040) and Day 90 (PSE vs. PLA: 28.42 ± 2.54 vs. 27.02 ± 3.55 hits; p = 0.002). On the same task, ART improved (treatment effect, p = 0.036) with PSE at Day 7 (PSE vs. PLA: 0.5896 ± 0.060 vs. 0.6141 ± 0.073 s; p = 0.049) and Day 30 (PSE vs. PLA: 0.5811 ± 0.068 vs. 0.6033 ± 0.055 s; p = 0.049). PSE also significantly increased hits (treatment effect, p = 0.020) at Day 30 (PSE vs. PLA: 19.25 ± 1.84 vs. 18.45 ± 1.48 hits; p = 0.007) and Day 90 (PSE vs. PLA: 19.39 ± 1.90 vs. 18.66 ± 1.64 hits; p = 0.026) for the multi-directional test with footplates. Significant differences were not observed in the remaining Makoto tests. PSE was well tolerated as evidenced by no effects observed in the blood safety panels.

conclusionsThe findings of the current study demonstrate that consumption of 900 mg of PSE improved specific measures of reactive agility in a young, active population.

trial registrationclinicaltrials.gov, NCT02518165 . Registered August 7, 2015 - retrospectively registered.

Indexed as

AdultCinnamatesDepsidesFemaleHumansMaleMentha spicataNootropic AgentsPlant ExtractsReaction TimeRosmarinic AcidYoung AdultCinnamatesDepsidesNootropic AgentsPlant ExtractsRosmarinic AcidAgilityCognitionMakotoNootropicPolyphenolsReaction timeRosmarinic acidSpearmint

Identifiers

PMID30541572
PMCPMC6291964
OpenAlexW2904452785

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.