ArticleBMC complementary and alternative medicine2018
Topical anti-inflammatory and anti-oxidative effects of porcine placenta extracts on 2,4-dinitrochlorobenzene-induced contact dermatitis.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Synergistic Enhancement of Facial Nerve Regeneration Using a Cellulose-Based Nerve Conduit Loaded with Mesenchymal Stem Cells and Human Placental Extract.Bioengineering (Basel, Switzerland) · 2026Article
- Exploratory evaluation of equine placental extract supplementation on ageing indicators in geriatric dogs: a single-arm pre-post study.BMC veterinary research · 2026Article
- Article
- Therapeutic effect of bosentan on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model.Archives of dermatological research · 2025Article
- Biological effects of human placental extracts - variations in manufacturing methods and compositions.Frontiers in pharmacology · 2025Review
- Characterization of Different Inflammatory Skin Conditions in a Mouse Model of DNCB-Induced Atopic Dermatitis.Inflammation · 2024Article
- Human placental extract suppresses mast cell activation and induces mast cell apoptosis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Establishment and Characterization of Mild Atopic Dermatitis in the DNCB-Induced Mouse Model.International journal of molecular sciences · 2023Article
- Design and Evaluation of Dissolvable Microneedles for Treating Atopic Dermatitis.Pharmaceutics · 2023Article
- Targeting estrogen signaling and biosynthesis for aged skin repair.Frontiers in physiology · 2023Review
- Enhancing the Effect of Placental Extract on the Regeneration of Crush Injured Facial Nerve.Experimental neurobiology · 2022Article
- Porcine placental extract increase the cellular NAD levels in human epidermal keratinocytes.Scientific reports · 2022Article
- Highly elastic 3D-printed gelatin/HA/placental-extract scaffolds for bone tissue engineering.Theranostics · 2022Article
- Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses.Cancer chemotherapy and pharmacology · 2021Article
- Anti-arthritic effect of chicken embryo tissue hydrolyzate against adjuvant arthritis in rats (X-ray microtomographic and histopathological analysis).Food science & nutrition · 2021Article
- ASPP 092, a phenolic diarylheptanoid fromSaudi journal of biological sciences · 2021Article
- Off-Flavor Removal from Sheep Placenta via Fermentation with Novel Yeast StrainMolecules (Basel, Switzerland) · 2021Article
- Porcine placenta extract improves high-glucose-induced angiogenesis impairment.BMC complementary medicine and therapies · 2021Article
- Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVEC angiogenesis in vitro.Stem cell research & therapy · 2021Article
- NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify.Pharmaceutics · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe placenta is a reservoir enriched with growth factors, hormones, cytokines and minerals. While several beneficial effects of placenta extracts on wound healing, anti-aging and anti-inflammatory responses have been reported, relatively limited mechanistic exploration has been conducted to date. Here, we provide compelling evidence of anti-inflammatory and anti-oxidative activities of porcine placenta extracts (PPE) against contact dermatitis in vivo.
methodsA contact dermatitis mouse model was established by sensitizing the dorsal skin of BALB/c mice using the contact allergen, 2,4-dinitrochlorobenzene (DNCB), and molecular consequences of topical application of PPE were investigated. PPEs were pre-sterilized via γ-irradiation, which is a milder but more effective way of sterilizing biomolecules relative to the conventional autoclaving method.
resultsDNCB-induced skin lesions displayed clear contact dermatitis-like symptoms and topical application of PPE dramatically alleviated both local and systemic inflammatory responses. Inflammatory epidermal thickening was completely abrogated and allergen-specific serum IgE levels significantly reduced in the presence of PPE. Moreover, anti-oxidative activities of PPE were observed both in vitro and in vivo, which may lead to attenuation of inflammatory responses. Prolonged treatment with PPE strongly inhibited production of DNCB-induced reactive oxygen species (ROS) and subsequently prevented oxidative degradation of hyaluronic acid (HA), which triggers innate inflammatory responses.
conclusionOur findings supply valuable insights into the mechanisms underlying the anti-inflammatory effects of PPE and provide a functional basis for the clinical application of PPE in inflammatory diseases.
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