ArticleSleep2019
Effect of sleep quality on amnestic mild cognitive impairment vulnerable brain regions in cognitively normal elderly individuals.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Effects of aerobic exercise interventions on cognitive function, sleep quality, and quality of life in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Sleep Quality and Aging: A Systematic Review on Healthy Older People, Mild Cognitive Impairment and Alzheimer's Disease.International journal of environmental research and public health · 2022Pooled it
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Article
- Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Anxious-depressive symptoms and sleep disturbances across the Alzheimer disease spectrum.Nature. Mental health · 2025Article
- Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden.Alzheimer's research & therapy · 2025Article
- Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults.Neurobiology of aging · 2025Article
- Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching.Journal of Zhejiang University. Science. B · 2025Article
- Poor sleep and decreased cortical thickness in veterans with mild traumatic brain injury and post-traumatic stress disorder.Military Medical Research · 2024Article
- Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Daytime Sleepiness, Apnea, Neuroimaging Correlates and Cortisol Dysregulation in a Memory Clinic Cohort.The journal of prevention of Alzheimer's disease · 2024Article
- Association between sleep quality and cognitive impairment in older adults hypertensive patients in China: a case-control study.Frontiers in public health · 2024Article
- Physical activity, sleep disorders, and type of work in the prevention of cognitive function decline in patients with hypertension.BMC public health · 2023Article
- Exposure to secondhand smoke is associated with poor sleep quality among non-smoking university students in Bangladesh: a cross-sectional survey.Scientific reports · 2023Article
- Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study.Behavioral and brain functions : BBF · 2023Article
- Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank.Sleep health · 2023Article
- Hippocampal Subfield Volumes in Amateur Marathon Runners.Medicine and science in sports and exercise · 2023Article
- Subjective and objective sleep quality does not predict behavioural episodic foresight in younger or older adults.Scientific reports · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesThis study aims to evaluate the extent to which sleep quality impacts amnestic mild cognitive impairment (aMCI)-related brain regions in a cognitively normal cohort of individuals.
methodsSeventy-four participants were rigorously evaluated using a battery of cognitive tests and a detailed clinical assessment to verify normal cognitive status. We then screened for sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and depressive symptoms using the Geriatric Depression Scale (GDS). Five subjects were excluded due to mild depression. Overall 38 individuals with mean age 70.7 ± 7 were classified as poor sleepers and 31 with mean age of 69.6 ± 6 years as normal sleepers. Structural MRI and Freesurfer brain parcellation were used to measure aMCI-related brain regions.
resultsRelative to normal sleepers, poor sleepers exhibited significant reductions in cortical and subcortical volumes bilaterally in the hippocampi, as well as in the superior parietal lobules and left amygdala. The effects were strongest in the left superior parietal lobule (p < .015), followed by the hippocampi. Diffuse patterns of cortical thinning were observed in the frontal lobes, but significant effects were concentrated in the right mesial frontal cortex. Lower sleep duration was most correlated with cortical volume and thickness reductions among all subjects.
conclusionsAtrophy related to poor sleep quality impacted a number of regions implicated in aMCI and Alzheimer's disease (AD). As such, interventions targeted towards improving sleep quality amongst the elderly may prove an effective tool for modulating the course of aMCI and AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.