ArticleCerebral cortex (New York, N.Y. : 1991)2019
The Cerebral Cortex is Bisectionally Segregated into Two Fundamentally Different Functional Units of Gyri and Sulci.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Frequency-specific gyro-sulcal functional differentiation in preterm neonates: Sulcal dominance and gene expression correlates.Developmental cognitive neuroscience · 2026Article
- The cellular and molecular basis of gyrus-sulcus specialization in the primate brain.Nature communications · 2026Article
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
- Subplate neuron dendritic morphology during development in gyrencephalic and lissencephalic brains.Scientific reports · 2026Article
- Multi-task machine learning reveals the functional neuroanatomy fingerprint of mental processing.bioRxiv : the preprint server for biology · 2025Article
- Cortical Morphological Networks Differ Between Gyri and Sulci.Neuroscience bulletin · 2025Article
- Advances in functional magnetic resonance imaging-based brain function mapping: a deep learning perspective.Psychoradiology · 2025Review
- Frequency-specific functional difference between gyri and sulci in naturalistic paradigm fMRI.Brain structure & function · 2024Article
- Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Temporal fingerprints of cortical gyrification in marmosets and humans.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A hybrid learning framework for fine-grained interpretation of brain spatiotemporal patterns during naturalistic functional magnetic resonance imaging.Frontiers in human neuroscience · 2022Article
- Fundamental functional differences between gyri and sulci: implications for brain function, cognition, and behavior.Psychoradiology · 2021Review
- Differential Patterns of Gyral and Sulcal Morphological Changes During Normal Aging Process.Frontiers in aging neuroscience · 2021Article
- Improving in vivo human cerebral cortical surface reconstruction using data-driven super-resolution.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- An investigation of CNN models for differentiating malignant from benign lesions using small pathologically proven datasets.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2019Article
- Temporal Variability of Cortical Gyral-Sulcal Resting State Functional Activity Correlates With Fluid Intelligence.Frontiers in neural circuits · 2019Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The human cerebral cortex is highly folded into diverse gyri and sulci. Accumulating evidences suggest that gyri and sulci exhibit anatomical, morphological, and connectional differences. Inspired by these evidences, we performed a series of experiments to explore the frequency-specific differences between gyral and sulcal neural activities from resting-state and task-based functional magnetic resonance imaging (fMRI) data. Specifically, we designed a convolutional neural network (CNN) based classifier, which can differentiate gyral and sulcal fMRI signals with reasonable accuracies. Further investigations of learned CNN models imply that sulcal fMRI signals are more diverse and more high frequency than gyral signals, suggesting that gyri and sulci truly play different functional roles. These differences are significantly associated with axonal fiber wiring and cortical thickness patterns, suggesting that these differences might be deeply rooted in their structural and cellular underpinnings. Further wavelet entropy analyses demonstrated the validity of CNN-based findings. In general, our collective observations support a new concept that the cerebral cortex is bisectionally segregated into 2 functionally different units of gyri and sulci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.