ArticleNucleic acids research2019
Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis.
Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 67 citations in OpenAlex.
- Advances in DNAzyme Selection, Molecular Engineering and Biomedical Applications.International journal of molecular sciences · 2026Review
- Enzyme-driven triplex structure-based DNA logic circuits.Journal of nanobiotechnology · 2025Article
- Functions and applications of enzymes in nucleic acid nanotechnology.Journal of nanobiotechnology · 2025Review
- An Intelligent Allosteric DNAzyme Platform for On-Site Uracil-DNA Glycosylase Imaging and On-Demand Gene Regulation.JACS Au · 2025Article
- Controllable and reusable seesaw circuit based on nicking endonucleases.Journal of nanobiotechnology · 2024Article
- DNAzymes: Expanding the Potential of Nucleic Acid Therapeutics.Nucleic acid therapeutics · 2023Review
- Reconfigurable DNA triplex structure for pH responsive logic gates.RSC advances · 2023Article
- Programming DNA Reaction Networks Using Allosteric DNA Hairpins.Biomolecules · 2023Article
- A DNA Finite-State Machine Based on the Programmable Allosteric Strategy of DNAzyme.International journal of molecular sciences · 2023Article
- Construction of Multiple Logic Circuits Based on Allosteric DNAzymes.Biomolecules · 2022Article
- Constructing DNA logic circuits based on the toehold preemption mechanism.RSC advances · 2021Article
- DNA Matrix Operation Based on the Mechanism of the DNAzyme Binding to Auxiliary Strands to Cleave the Substrate.Biomolecules · 2021Article
- Development of a neuron model based on DNAzyme regulation.RSC advances · 2021Article
- Sensitive Detection of Nucleic Acids Using Subzyme Feedback Cascades.Molecules (Basel, Switzerland) · 2020Article
- DNA circuits driven by conformational changes in DNAzyme recognition arms.RSC advances · 2020Article
- Constructing Controllable Logic Circuits Based on DNAzyme Activity.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, due to the dual roles of DNA and enzyme, DNAzyme has been widely used in the field of DNA circuit, which has a wide range of applications in bio-engineered system, information processing and biocomputing. In fact, the activity of DNAzymes was regulated by subunits assembly, pH control and metal ions triggers. However, those regulations required to change the sequences of whole DNAzyme, as separating parts and inserting extra DNA sequence. Inspired by the allosteric regulation of proteins in nature, a new allosteric strategy is proposed to regulate the activity of DNAzyme without DNA sequences changes. In this strategy, DNA strand displacement was used to regulate the DNAzyme structure, through which the activity of DNAzyme was well controlled. The strategy was applied to E6-type DNAzymes, and the operations of DNA logic circuit (YES, OR, AND, cascading and feedback) were established and simulated with the dynamic analyses. The allosteric regulation has potential to construct more complicated molecular systems, which can be applied to bio-sensing and detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.