ArticleThe American journal of clinical nutrition2018
Severe vitamin D deficiency is a risk factor for renal hyperfiltration.
Article in The American journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pooled it
- Association of Vitamin D Levels and Mortality in Overactive Bladder: Nonlinear Dose-Response and Threshold Effect.Food science & nutrition · 2026Article
- The Vicious Cycle of Diabetic Kidney Disease, Vitamin D Deficiency, and Arterial Hypertension.Healthcare (Basel, Switzerland) · 2026Review
- Correlations and influencing factors of vitamin A and D levels in maternal and neonatal cord blood among pregnant women.Frontiers in endocrinology · 2026Article
- Hypovitaminosis D Does Not Aggravate the Progression of Gentamicin-Induced Kidney Injury in Rats.Diseases (Basel, Switzerland) · 2025Article
- Renal Hyperfiltration as a New Mechanism of Smoking-Related Mortality.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Validation Study of Physical Activity and Sedentary Behavior in African-American Men and Women.Journal of racial and ethnic health disparities · 2024Article
- Review
- The association between renal hyperfiltration and mortality is not mediated by diabetes mellitus.International urology and nephrology · 2023Article
- Circulating Fibroblast Growth Factor-23 Levels Can Predict Rapid Kidney Function Decline in a Healthy Population: A Community-Based Study.Biomolecules · 2022Article
- Serum Cystatin C Levels Could Predict Rapid Kidney Function Decline in A Community-Based Population.Biomedicines · 2022Article
- Association between serum 25-hydroxyvitamin-D and Triglycerides-Glucose index among Indian adolescents.BMC nutrition · 2022Article
- Mendelian randomization reveals causal effects of kidney function on various biochemical parameters.Communications biology · 2022Article
- Mortality-based definition of renal hyperfiltration in middle-aged men: a 35-year cohort from Finland.International urology and nephrology · 2022Article
- Associations Between 25-Hydroxyvitamin D, Kidney Function, and Insulin Resistance Among Adults in the United States of America.Frontiers in nutrition · 2021Article
- Vitamin D deficiency and kidney hyperfiltration: a mechanism of kidney injury?Annals of translational medicine · 2019Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population. Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Design: Data were retrieved from the Korean NHANES, a nationwide population-based cross-sectional study from 2008 to 2015. Overall, 33,210 subjects with normal renal function were included in the final analysis. Severe vitamin D deficiency was defined as serum 25-hydroxyvitamin D concentration <10 ng/mL. RHF was defined as estimated glomerular filtration rate with residual in the >95th percentile after adjustment for age, sex, height, weight, and history of hypertension or diabetes. Results: The mean ± SD age of subjects was 48.1 ± 15.9 y, and the number of women was 18,779 (56.5%). Estimated glomerular filtration rate was negatively associated with serum 25-hydroxyvitamin D concentrations in multivariable linear regression analysis (β: -0.02; 95% CI: -0.02, -0.01; P < 0.001). Furthermore, 1637 (4.9%) subjects were categorized into the RHF group, and the prevalence of RHF was significantly higher in the severe vitamin D deficiency group than in the sufficiency group (5.8% compared with 5.0%, P < 0.001). In a multivariable logistic regression model, severe vitamin D deficiency was a significant risk factor for RHF (OR: 2.41; 95% CI, 1.72, 3.43; P < 0.001). Conclusions: Severe vitamin D deficiency is significantly associated with increasing prevalence of RHF in a relatively healthy adult population.
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