ArticlePloS one2018
Disruption of the microbiota affects physiological and evolutionary aspects of insecticide resistance in the German cockroach, an important urban pest.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Comparative Evaluation of Enrichment and Selective Culture Strategies for DetectingVector borne and zoonotic diseases (Larchmont, N.Y.) · 2026Article
- Group recognition in the German cockroach, a subsocial omnivore, is based on faecal odour preference that is modulated by coprophagy, diet and learning.Proceedings. Biological sciences · 2026Article
- Article
- Midgut microbiota profiling of Blattella germanica (Blattodea: Ectobiidae).Journal of insect science (Online) · 2026Article
- Metagenomic analysis of gut bacteria in different developmental instars ofMicrobiology spectrum · 2026Article
- Multi-omics of cockroaches infected with Salmonella Typhimurium identifies molecular signatures of vector colonization.BMC genomics · 2025Article
- Direct and transgenerational effects of tetracyclines on the microbiome, transcriptome, and male mating behavior of the sheep blowfly Lucilia cuprina.G3 (Bethesda, Md.) · 2025Article
- Article
- Indoor Allergen Interventions in Homes and Schools for Managing Asthma.The journal of allergy and clinical immunology. In practice · 2025Review
- Invasive indoor pests under the microbiological lens: bacterial and viral diversity from local to global scales in bed bugs and cockroaches.Current opinion in insect science · 2025Review
- Pathogenicity and host-interacting mechanisms of enterogenicFrontiers in microbiology · 2025Article
- The gut microbiota confers resistance againstiScience · 2024Article
- Cereal leaf beetle-associated bacteria enhance the survival of their host upon insecticide treatments and respond differently to insecticides with different modes of action.Environmental microbiology reports · 2024Article
- Gut Microbiota Is Not Essential for Survival and Development inLife (Basel, Switzerland) · 2024Article
- Article
- An Insider's Perspective about the Pathogenic Relevance of Gut Bacterial Transportomes.Microbial physiology · 2024Review
- Insect Microbial Symbionts: Ecology, Interactions, and Biological Significance.Microorganisms · 2023Review
- Pesticide exposure and the microbiota-gut-brain axis.The ISME journal · 2023Review
- Effects of copper and zinc oxide nanoparticles on German cockroach development, indoxacarb resistance, and bacterial load.Pest management science · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The German cockroach, Blatella germanica, is a common pest in urban environments and is among the most resilient insects in the world. The remarkable ability of the German cockroach to develop resistance when exposed to toxic insecticides is a prime example of adaptive evolution and makes control of this insect an ongoing struggle. Like many other organisms, the German cockroach is host to a diverse community of symbiotic microbes that play important roles in its physiology. In some insect species, there is a strong correlation between the commensal microbial community and insecticide resistance. In particular, several bacteria have been implicated in the detoxification of xenobiotics, including synthetic insecticides. While multiple mechanisms that mediate insecticide resistance in cockroaches have been discovered, significant knowledge gaps still exist in this area of research. Here, we examine the effects of altering the microbiota on resistance to a common insecticide using antibiotic treatments. We describe an indoxacarb-resistant laboratory strain in which treatment with antibiotic increases susceptibility to orally administered insecticide. We further reveal that this strains harbors a gut microbial community that differs significantly from that of susceptible cockroaches in which insecticide resistance is unaffected by antibiotic. More importantly, we demonstrate that transfer of gut microbes from the resistant to the susceptible strain via fecal transplant increases its resistance. Lastly, our data show that antibiotic treatment adversely affects several reproductive life-history traits that may contribute to the dynamics of resistance at the population level. Together these results suggest that the microbiota contributes to both physiological and evolutionary aspects of insecticide resistance and that targeting this community may be an effective strategy to control the German cockroach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.