ArticleJournal of neurophysiology2019
Automated home cage training of mice in a hold-still center-out reach task.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The role of dopamine-sensitive motor cortical circuits in the development and execution of skilled forelimb movements.iScience · 2026Article
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Article
- A novel biomechanical model of the proximal mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.Journal of neurophysiology · 2025Article
- Article
- Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task.Journal of neurophysiology · 2024Article
- Exploration biases forelimb reaching strategies.Cell reports · 2024Article
- Full field-of-view virtual reality goggles for mice.Neuron · 2023Article
- Learning-induced changes in the neural circuits underlying motor sequence execution.Current opinion in neurobiology · 2022Review
- Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes.Science advances · 2022Article
- Distributed and Localized Dynamics Emerge in the Mouse Neocortex during Reach-to-Grasp Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Efficient training approaches for optimizing behavioral performance and reducing head fixation time.PloS one · 2022Article
- Impaired Refinement of Kinematic Variability in Huntington Disease Mice on an Automated Home Cage Forelimb Motor Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors.Journal of neural engineering · 2021Article
- Automation of training and testing motor and related tasks in pre-clinical behavioural and rehabilitative neuroscience.Experimental neurology · 2021Review
- New roles for dopamine in motor skill acquisition: lessons from primates, rodents, and songbirds.Journal of neurophysiology · 2021Review
- Article
- Towards Cell and Subtype Resolved Functional Organization: Mouse as a Model for the Cortical Control of Movement.Neuroscience · 2020Review
- Online control of reach accuracy in mice.Journal of neurophysiology · 2020Article
- Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages.eLife · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
An obstacle to understanding neural mechanisms of movement is the complex, distributed nature of the mammalian motor system. Here we present a novel behavioral paradigm for high-throughput dissection of neural circuits underlying mouse forelimb control. Custom touch-sensing joysticks were used to quantify mouse forelimb trajectories with micron-millisecond spatiotemporal resolution. Joysticks were integrated into computer-controlled, rack-mountable home cages, enabling batches of mice to be trained in parallel. Closed loop behavioral analysis enabled online control of reward delivery for automated training. We used this system to show that mice can learn, with no human handling, a direction-specific hold-still center-out reach task in which a mouse first held its right forepaw still before reaching out to learned spatial targets. Stabilogram diffusion analysis of submillimeter-scale micromovements produced during the hold demonstrate that an active control process, akin to upright balance, was implemented to maintain forepaw stability. Trajectory decomposition methods, previously used in primates, were used to segment hundreds of thousands of forelimb trajectories into millions of constituent kinematic primitives. This system enables rapid dissection of neural circuits for controlling motion primitives from which forelimb sequences are built. NEW & NOTEWORTHY A novel joystick design resolves mouse forelimb kinematics with micron-millisecond precision. Home cage training is used to train mice in a hold-still center-out reach task. Analytical methods, previously used in primates, are used to decompose mouse forelimb trajectories into kinematic primitives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.