Evidence map›Paper›PMID 30540233›Full record

ReviewPhysiology (Bethesda, Md.)2019

Scaling of Motor Output, From Mouse to Humans.

Marin Manuel, Matthieu Chardon, Vicki Tysseling, C J Heckman

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A consensus spinal cord cell type atlas across mouse, macaque, and human.bioRxiv : the preprint server for biology · 2026
    Article
  7. Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026
    Review
  8. Machine-Learning Classification of Motor Unit Types in the Adult Mouse.bioRxiv : the preprint server for biology · 2025
    Article
  9. Motor unit mechanisms of speed control in mouse locomotion.bioRxiv : the preprint server for biology · 2025
    Article
  10. A Multi-Scale, High-Fidelity Computational Model of the Mouse Triceps Surae Motor Pool.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marin ManuelCentre de Neurophysique, Physiologie, et Pathologie, UMR 8119 CNRS/Université Paris Descartes , Paris , France.
Matthieu ChardonPhysiology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
Vicki TysselingPhysical Therapy and Human Movement Sciences, Physiology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
C J HeckmanPhysiology, Physical Medicine and Rehabilitation, Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine , Chicago, Illinois.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)TL1TR001423 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCCOLLEY, SUSANNA A · 2015 to 2023
$5.0M
Electrical and mechanical properties of motor units in a mouse model of ALSR01NS077863 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2011 to 2015
$2.6M
Effect of Injury Severity and Location on Spasms Post SCIK01HD084672 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TYSSELING, VICKI M · 2015 to 2019
$653k
NCATS NIH HHS TL1 TR001423NICHD NIH HHS K01 HD084672NINDS NIH HHS R01 NS077863
6 · The paper itself

Abstract

Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scaling differences need to be taken into account for the use of rodents for translational studies of motor output.

Indexed as

AnimalsHumansMiceMotor NeuronsMovementMuscle, Skeletal

Identifiers

PMID30540233
PMCPMC6383635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.