Evidence map›Paper›PMID 30540229›Full record

ReviewPhysiology (Bethesda, Md.)2019

Cardiac Vagus and Exercise.

Alexander V Gourine, Gareth L Ackland

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05619107 (Transauricular Nerve Stimulation to Enhance Exercise Capacity), which is not on this map. Cited by 61 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05619107 nacompletednot on this mapstarted 2022, after this paper: background citation

Transauricular Nerve Stimulation to Enhance Exercise Capacity: Protocol for a Double-blind, Open Crossover, Randomised Sham-controlled Trial

TypeinterventionalSponsorQueen Mary University of LondonRan2022 to 2023Enrolled28ConditionsAging, Inflammation, Cardiovascular DiseasesArmsActive Transauricular nerve stimulation, Sham transauricular nerve stimulation
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Transcutaneous vagus nerve stimulation and exercise-induced autonomic regulation: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. The effects of exercise training on hypertensive older adults: an umbrella meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Cardiac vagal motor neurons.Current opinion in neurobiology · 2025
    Review
  14. Article
  15. Review
  16. Observational
  17. Cardiac autonomic function in young, healthy adults: Influence of race and sex.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London , London , United Kingdom.
Gareth L AcklandWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom.
University College London · GBWilliam Harvey Research Institute · GB

Funding

British Heart Foundation RG/14/4/30736Wellcome Trust 200893Wellcome Trust 200893/Z/16/Z
6 · The paper itself

Abstract

Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in experimental studies using the latest advances in molecular neuroscience, combined with human exercise physiology, physiological modeling, and genomic data suggest that the strength of cardiac vagal activity causally determines our ability to exercise.

Indexed as

AnimalsExerciseHeartHeart RateHumansPhysical Conditioning, AnimalVagus Nerve

Identifiers

PMID30540229
PMCPMC6383634
OpenAlexW2905374123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.