Evidence map›Paper›PMID 30539419›Full record

ArticleCellular and molecular neurobiology2019

The Effect of MPP+ on the Viability of Primary Cortical Astrocytes Isolated from Female and Male Wistar Rats of Different Ages.

Adriana Alarcón-Aguilar, Armando Luna-López, Norma Edith López-Diazguerrero, Mina Königsberg

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Adriana Alarcón-AguilarDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, 09340, Ciudad de México, Mexico.
Armando Luna-LópezInstituto Nacional de Geriatría, SSA, 10200, Ciudad de México, Mexico.
Norma Edith López-DiazguerreroDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, 09340, Ciudad de México, Mexico.
Mina KönigsbergDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, 09340, Ciudad de México, Mexico. mkf@xanum.uam.mx.

Funding

CONACYT FON.INST/298/2016
6 · The paper itself

Abstract

Although age is known to be the main risk for developing chronic and neurodegenerative diseases, those illnesses have a different prevalence depending on the sex. It has been questioned whether genetic and hormonal differences are preserved in primary cultures from individuals of different genders. Therefore, here we studied the susceptibility of astrocytes, obtained from female and male Wistar rats of different ages (newborn, 9 and 24 months-old), to the well-known toxin MPP+ after 2 weeks in vitro, at different concentrations and exposure times. Our results showed that there are no variances due to gender, but that there are important differences associated to age in terms of the viability against this toxin.

Indexed as

1-Methyl-4-phenylpyridiniumAgingAnimalsAstrocytesCells, CulturedCell SeparationCell SurvivalCerebral CortexFemaleHydrogen PeroxideMaleRats, Wistar1-Methyl-4-phenylpyridiniumHydrogen PeroxideAgeAstrocytesGenderMPP+RatsSex

Identifiers

PMID30539419
PMCPMC11469902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.