Evidence map›Paper›PMID 30539292›Full record

ArticleClinical oral investigations2019

Estrogen receptor gene is associated with dental fluorosis in Brazilian children.

M Dalledone, A S Cunha, L A Ramazzotto, G D Pecharki, P Nelson-Filho, R Scariot, P C Trevilatto, A R Vieira, Erika C Küchler, João A Brancher

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Advances in epidemiological status and pathogenesis of dental fluorosis.Frontiers in cell and developmental biology · 2023
    Review
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

M DalledoneSchool of Health and Biological Sciences, Universidade Positivo, Rua Professor Pedro Viriato Parigot de Souza, 5300, Campo Comprido, Curitiba, Paraná, 80740-050, Brazil.
A S CunhaDepartment of Pediatric Dentistry - School of Dentistry of Ribeirão Preto, University of São Paulo, USP, Avenida do Café s/n, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
L A RamazzottoDepartment of Pediatric Dentistry - School of Dentistry of Ribeirão Preto, University of São Paulo, USP, Avenida do Café s/n, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
G D PecharkiDepartment of Community Health, Federal University of Parana, Curitiba, Brazil.
P Nelson-FilhoDepartment of Pediatric Dentistry - School of Dentistry of Ribeirão Preto, University of São Paulo, USP, Avenida do Café s/n, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
R ScariotSchool of Health and Biological Sciences, Universidade Positivo, Rua Professor Pedro Viriato Parigot de Souza, 5300, Campo Comprido, Curitiba, Paraná, 80740-050, Brazil.
P C TrevilattoSchool of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
A R VieiraDepartment of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Erika C KüchlerSchool of Health and Biological Sciences, Universidade Positivo, Rua Professor Pedro Viriato Parigot de Souza, 5300, Campo Comprido, Curitiba, Paraná, 80740-050, Brazil. erikacalvano@gmail.com.
João A BrancherSchool of Health and Biological Sciences, Universidade Positivo, Rua Professor Pedro Viriato Parigot de Souza, 5300, Campo Comprido, Curitiba, Paraná, 80740-050, Brazil. brancher.a@gmail.com.ORCID http://orcid.org/0000-0002-8914-702X
Universidade de Ribeirão Preto · BRUniversidade Positivo · BRPontifícia Universidade Católica do Paraná · BRUniversidade de São Paulo · BRUniversidade Federal do Paraná · BRUniversity of Pittsburgh · US

Funding

The State of São Paulo Research Foundation 2015/06866-5
6 · The paper itself

Abstract

objectivesThe aim of this study was investigate the association between genetic polymorphisms in ESR1, ESR2, and ESRRB and dental fluorosis (DF) in a well-characterized sample of children from Curitiba, Brazil. MATERIAL AND

methodsFrom a representative sample of 538 children, 12-year-old were evaluated. DF was assessed in erupted permanent teeth by the Dean's index modified. Fourteen polymorphisms were selected in intronic and intergenic regions of ESR1, ESR2, and ESRRB and genotyped in genomic DNA source from saliva using TaqMan chemistry and end-point analysis. Allele and genotype distributions between DF and DF free groups were analyzed using the Epi Info 7.2. Chi-square or Fisher's exact tests at a level of significance of 5% and odds ratios calculations with 95% confidence intervals were used to determine the statistical associations.

resultsAmong 538 children, 147 were DF and 391 were DF free. Genotype distribution for the polymorphism rs12154178 in ESR1 was different between the two groups (p = 0.037; OR = 0.91; CI = 0.67-1.22). The dominant model analysis (AA+AC vs. CC) demonstrated that CC is a protective factor for DF (p = 0.038; OR = 0.51, 0.27-0.97 95% CI). We did not find differences in frequency distributions in the other evaluated polymorphisms.

conclusionThis study provides evidence that ESR1 is associated with DF. CLINICAL RELEVANCE: Dental fluorosis is an important condition that affects the mineralized tissues of the teeth. In severe cases, the treatment takes time and is extremely costly. This research provides evidences that there are genetic factors involved in dental fluorosis and will help professionals to plan more precise strategies to reduce dental fluorosis occurrence.

Indexed as

Fluorosis, DentalReceptors, EstrogenAllelesBrazilChildEstrogen Receptor alphaEstrogen Receptor betaGenotypeHumansESR1 protein, humanESR2 protein, humanESRRB protein, humanEstrogen Receptor alphaEstrogen Receptor betaReceptors, EstrogenDental fluorosisEstrogen receptor genePolymorphism

Identifiers

PMID30539292
OpenAlexW2904306230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.