Evidence map›Paper›PMID 30539267›Full record

ArticlePsychopharmacology2019

Neuronal nitric oxide synthase activity mediates Lycium barbarum polysaccharides-enhanced sexual performance without stimulating noncontact erection in rats.

Andy C Huang, Jia-Min Wu, Ya-Han Chang, Navneet Kumar Dubey, Allen W Chiu, Chien-Yu Yeh, Tung-Hu Tsai, Kuei-Ying Yeh

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Andy C HuangInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Jia-Min WuDepartment of Physical Therapy, Hung Kuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung, 43302, Taiwan.
Ya-Han ChangDepartment of Physical Therapy, Hung Kuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung, 43302, Taiwan.
Navneet Kumar DubeyCeramics and Biomaterials Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Allen W ChiuInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Chien-Yu YehDepartment of Nursing, Ching Kuo Institute of Management and Health, Keelung, Taiwan.
Tung-Hu TsaiInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Kuei-Ying YehDepartment of Physical Therapy, Hung Kuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung, 43302, Taiwan. d93441003@ntu.edu.tw.
Hungkuang University · TWNational Yang Ming Chiao Tung University · TWChing Kuo Institute of Management and Health · TWNational Yang Ming Chiao Tung University · TWTon Duc Thang University · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleLycium barbarum polysaccharide (LBP) is known to promote reproductive functions. However, its role in noncontact erection (NCE) of penis initiated by brain regions including medial preoptic area (MPOA) and paraventricular nucleus (PVN) regions responsible for sexual behavior has not been investigated.

objectivesTherefore, this study initially investigated the effects of LBP on male sexual function, and subsequently, the mechanistic insight was investigated through assessing the expression of neuronal nitric oxide synthase (nNOS) in the MPOA and PVN.

methodsThe adult male rats were treated with 100 mg/kg of LBP or vehicle by oral gavage. Before and after 14 days of treatment, copulatory behavior and noncontact erection (NCE) were recorded. After the last behavioral test, the brain was isolated to measure nNOS expression in the MPOA and PVN.

resultsData showed that LBP treatment significantly increased both the frequencies of intromission as well as ejaculation, compared to the control group. Whereas, a reduced post-ejaculatory interval was observed compared to same group on day 0. Furthermore, the treatment led to an increased intromission ratio, inter-intromission interval, and the number of MPOA nNOS-immunoreactive cells (nNOS-ir). Additionally, a significantly positive correlation between ejaculation frequency and MPOA nNOS-ir cells was recorded. Of note, LBP treatment had no effects on NCE and PVN nNOS-ir expression.

conclusionThese findings suggest that LBP enhances sexual behavior through increased nNOS expression in the MPOA in male rats.

Indexed as

AnimalsDrugs, Chinese HerbalEnzyme ActivationFemaleMaleNeuronsNitric OxideNitric Oxide Synthase Type IParaventricular Hypothalamic NucleusPenile ErectionPreoptic AreaRatsRats, Long-EvansSexual Behavior, AnimalTestisDrugs, Chinese Herballycium barbarum polysaccharideNitric OxideNitric Oxide Synthase Type ILycium barbarum polysaccharideMedial preoptic areanNOSNoncontact erectionParaventricular nucleusSexual behavior

Identifiers

PMID30539267
OpenAlexW2904061970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.