ArticleApplied microbiology and biotechnology2019
International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans.
Article in Applied microbiology and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Low-Intensity, Short-Duration Proton Irradiation Enhances Oxidative Stress Sensitivity ofJournal of fungi (Basel, Switzerland) · 2026Article
- Microgravity-induced constraints on melanin bioproduction: investigating E. coli metabolic responses aboard the international space station.NPJ microgravity · 2026Article
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- Effects of simulated microgravity on biological features and virulence of the fungal pathogenApplied and environmental microbiology · 2025Article
- Fungal graviresponses: Physiological and molecular insights from tissue reorientation in the gravity vector.Mycology · 2025Review
- Microbiology of human spaceflight: microbial responses to mechanical forces that impact health and habitat sustainability.Microbiology and molecular biology reviews : MMBR · 2024Review
- Space exposure enhanced pectin-degrading enzymes expression and activity in Aspergillus costaricaensis.World journal of microbiology & biotechnology · 2023Article
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- Complementary Strategies to Unlock Biosynthesis Gene Clusters Encoding Secondary Metabolites in the Filamentous FungusJournal of fungi (Basel, Switzerland) · 2022Article
- The International Space Station Environment Triggers Molecular Responses inFrontiers in microbiology · 2022Article
- Draft Genome Sequences of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment.Microbiology resource announcements · 2021Article
- Advances in space microbiology.iScience · 2021Review
- Article
- Effects of Simulated Microgravity on the Proteome and Secretome of the Polyextremotolerant Black FungusFrontiers in genetics · 2021Article
- Transcriptomic and genomic changes associated with radioadaptation inComputational and structural biotechnology journal · 2021Article
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- Validating an Automated Nucleic Acid Extraction Device forFrontiers in microbiology · 2020Article
- Fitness of Outer Membrane Vesicles FromFrontiers in microbiology · 2020Article
- Metabolomic Analysis ofFrontiers in microbiology · 2020Article
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12 authors.
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Abstract
The first global genomic, proteomic, and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space Station (ISS) is reported. The investigation included the A. nidulans wild-type and three mutant strains, two of which were genetically engineered to enhance secondary metabolite production. Whole genome sequencing revealed that ISS conditions altered the A. nidulans genome in specific regions. In strain CW12001, which features overexpression of the secondary metabolite global regulator laeA, ISS conditions induced the loss of the laeA stop codon. Differential expression of proteins involved in stress response, carbohydrate metabolic processes, and secondary metabolite biosynthesis was also observed. ISS conditions significantly decreased prenyl xanthone production in the wild-type strain and increased asperthecin production in LO1362 and CW12001, which are deficient in a major DNA repair mechanism. These data provide valuable insights into the adaptation mechanism of A. nidulans to spacecraft environments.
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