Evidence map›Paper›PMID 30539254›Full record

ReviewPediatric nephrology (Berlin, Germany)2020

Diagnostics, treatment, and immune response in BK polyomavirus infection after pediatric kidney transplantation.

Thurid Ahlenstiel-Grunow, Lars Pape

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. An updated approach to the evaluation of the urinary sediment.Pediatric nephrology (Berlin, Germany) · 2025
    Review
  5. Article
  6. Review
  7. Virus-specific T cells in pediatric renal transplantation.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thurid Ahlenstiel-GrunowDepartment of Pediatric Kidney, Liver and Metabolic Disease, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. Ahlenstiel.Thurid@mh-hannover.de.
Lars PapeDepartment of Pediatric Kidney, Liver and Metabolic Disease, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-3635-6418
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After pediatric kidney transplantation BK polyomavirus (BKPyV) infections are associated with an increased risk of graft loss by BKPyV-associated nephropathy (BkPyVAN). However, suitable prognostic markers for the individual outcome of BKPyV infections are missing and the management of therapeutic interventions remains a challenge to the success of pediatric kidney transplantation. This review gives an overview on current diagnostic and therapeutic strategies in the field of BKPyV infections after pediatric kidney transplantation. Methods determining the individual immune response to BKPyV are described and their usability is discussed. There is growing evidence that BKPyV-specific T cells (BKPyV-Tvis) may serve as prognostic markers in order to steer immunosuppressive therapy in pediatric kidney recipients with BKPyV viremia in future. Prospective randomized trials in viremic kidney recipients comparing Tvis-steered therapeutic intervention with standard reduction of immunosuppression are needed before implementation of BKPyV-Tvis monitoring in routine care of BKPyV infections.

Indexed as

AllograftsAntiviral AgentsBK VirusChildDNA, ViralFluoroquinolonesGraft RejectionHumansImmunosuppression TherapyImmunosuppressive AgentsKidneyKidney TransplantationPolyomavirus InfectionsPrognosisRandomized Controlled Trials as TopicT-LymphocytesAntiviral AgentsDNA, ViralFluoroquinolonesImmunosuppressive AgentsMTOR protein, humanTOR Serine-Threonine KinasesBK polyomavirusBK polyomavirus-associated nephropathyImmunosuppressionKidney transplantationmTOR inhibitorsPediatric transplantationPrognostic markerViral infectionsVirus-specific T cells

Identifiers

PMID30539254
OpenAlexW2905502032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.