ArticleEuropean archives of psychiatry and clinical neuroscience2020
Use of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study.
Article in European archives of psychiatry and clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Z-drug abuse and dependence: clinical guideline of the Brazilian Academy of Neurology for diagnosis and management.Arquivos de neuro-psiquiatria · 2025Guideline
- The Incidence of Benzodiazepine and Benzodiazepine-Related Drug Use in People With and Without Parkinson's Disease-A Nationwide Cohort Study.Basic & clinical pharmacology & toxicology · 2025Article
- Pharmacotherapy of psychiatric inpatients with mental and behavioral disorders caused by sedatives or hypnotics (F13): Results from an observational pharmacovigilance program between 2000 and 2017.Addiction science & clinical practice · 2025Observational
- Medical Professionals and Pharmacological Intervention for the Treatment of Insomnia: A Cross-Sectional Study.Sleep science (Sao Paulo, Brazil) · 2025Article
- Psychiatric and racial/ethnic differences in incident and long-term benzodiazepine use: A commercial healthcare claims study.Journal of psychiatric research · 2025Article
- Prevalence and Associated Factors of Benzodiazepine Use in Patients Attending a Community Mental Health Team in Scotland: A Cross-Sectional Survey.Clinical practice and epidemiology in mental health : CP & EMH · 2025Article
- Psychosocial characteristics of the general population who habitually use hypnotics: Results from a national survey on drug use among the Japanese.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Long-term benzodiazepine use and risk of labor market marginalization in Finland: A cohort study with 5-year follow-up.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- New users of anxiolytics and sedatives in Sweden-Drug type, doses, prescribers' characteristics, and psychiatric comorbidity in more than 750,000 patients.International journal of methods in psychiatric research · 2024Article
- Trajectories of Benzodiazepine Use among Older Adults from a Concordance-with-Guidelines Perspective: A Nationwide Cohort Study.Drugs & aging · 2023Article
- Effects of Japanese policies and novel hypnotics on long-term prescriptions of hypnotics.Psychiatry and clinical neurosciences · 2023Article
- A Comparison between Perceptions of Psychiatric Outpatients and Psychiatrists Regarding Benzodiazepine Use and Decision Making for Its Discontinuation: A Cross-Sectional Survey in Japan.International journal of environmental research and public health · 2023Article
- Potentially inappropriate medication use by level of polypharmacy among US Veterans 49-64 and 65-70 years old.Pharmacoepidemiology and drug safety · 2022Article
- Trends in the Use of Anxiolytics in Castile and Leon, Spain, between 2015-2020: Evaluating the Impact of COVID-19.International journal of environmental research and public health · 2021Article
- Neuroenhancement: State of the Art and Future Perspectives.Clinical neuropsychiatry · 2021Article
- Pharmacological Treatment of Schizophrenia: Japanese Expert Consensus.Pharmacopsychiatry · 2021Article
- The Burden of Potentially Inappropriate Medications in Chronic Polypharmacy.Journal of clinical medicine · 2020Article
- Misuse of benzodiazepines: Prevalence and impact in an inpatient population with psychiatric disorders.British journal of clinical pharmacology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Benzodiazepines and z-drugs are primarily indicated for the treatment of sleep disorders and anxiety symptoms. Their frequent long-term use contrasts with the international guidelines that limit treatment duration to a maximum of 4 weeks. The objective of this study was to assess the frequency of their use that was not in accordance with guidelines in the French general population between 2007 and 2012 and associated characteristics. A cohort of 67,550 benzodiazepine new users was set up in an exhaustive database for health-care reimbursements and representative of the French population. Benzodiazepine use not in accordance with guidelines was defined as the concomitant dispensation of several benzodiazepines, the dispensation of treatment over a period longer than recommended, or a new dispensing within the 2 months following the end of a previous treatment of maximum recommended duration, considering that French recommendations distinguish between hypnotic (4 weeks) and anxiolytic benzodiazepines (12 weeks). Benzodiazepine use not in accordance with guidelines was high, in about 30% of new hypnotic users and 20% of new anxiolytic users. Its frequency was stable over the study period. Associated characteristics were similar for new hypnotic or anxiolytic users, i.e.. older age, treatment initiation by a psychiatrist, presence of a chronic disease, hospitalization, or another psychotropic treatment. These findings provide a solid basis for establishing a public health policy to reduce benzodiazepine use not compliant with guidelines. They should be further explored in patients most at risk in the present study, e.g., patients treated by a psychiatrist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.