ArticleScience advances2018
Engineering a light-responsive, quorum quenching biofilm to mitigate biofouling on water purification membranes.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Biofilm engineering through c-di-GMP tuning boosts bioleaching efficiency and arsenic tolerance inApplied and environmental microbiology · 2026Article
- Engineered Marine Biofilms for Ocean Environment Monitoring.ACS synthetic biology · 2025Article
- Extracellular electron transfer proteins contribute to reduction of ferric minerals byApplied and environmental microbiology · 2025Article
- Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology.Microbial biotechnology · 2025Review
- Energy and nutrient recovery from municipal and industrial waste and wastewater-a perspective.Journal of industrial microbiology & biotechnology · 2024Review
- Long-term imaging and spatio-temporal control of living cells using targeted light based on closed-loop feedback.Journal of micro-bio robotics · 2024Article
- Microstructure optimization of bioderived polyester nanofilms for antibiotic desalination via nanofiltration.Science advances · 2023Article
- Optogenetics in bacteria - applications and opportunities.FEMS microbiology reviews · 2022Review
- When microbial biotechnology meets material engineering.Microbial biotechnology · 2022Article
- Engineered microbial consortia: strategies and applications.Microbial cell factories · 2021Review
- Steering Molecular Activity with Optogenetics: Recent Advances and Perspectives.Advanced biology · 2021Review
- Ways to control harmful biofilms: prevention, inhibition, and eradication.Critical reviews in microbiology · 2021Review
- Construction of an Acetate Metabolic Pathway to Enhance Electron Generation of EngineeredFrontiers in bioengineering and biotechnology · 2021Article
- Engineering controllable biofilms for biotechnological applications.Microbial biotechnology · 2021Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum quenching (QQ) has been reported to be a promising approach for membrane biofouling control. Entrapment of QQ bacteria in porous matrices is required to retain them in continuously operated membrane processes and to prevent uncontrollable biofilm formation by the QQ bacteria on membrane surfaces. It would be more desirable if the formation and dispersal of biofilms by QQ bacteria could be controlled so that the QQ bacterial cells are self-immobilized, but the QQ biofilm itself still does not compromise membrane performance. In this study, we engineered a QQ bacterial biofilm whose growth and dispersal can be modulated by light through a dichromatic, optogenetic c-di-GMP gene circuit in which the bacterial cells sense near-infrared (NIR) light and blue light to adjust its biofilm formation by regulating the c-di-GMP level. We also demonstrated the potential application of the engineered light-responsive QQ biofilm in mitigating biofouling of water purification forward osmosis membranes. The c-di-GMP-targeted optogenetic approach for controllable biofilm development we have demonstrated here should prove widely applicable for designing other controllable biofilm-enabled applications such as biofilm-based biocatalysis.
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