ArticleVirusdisease2018
PR8 virus harbouring H5N1
Article in Virusdisease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based influenza model.Frontiers in microbiology · 2025Article
- Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive Review.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024Review
- The Role of Innate Leukocytes during Influenza Virus Infection.Journal of immunology research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Innate immune cells are key player in immune response to influenza virus infection. Influenza infected monocytes exacerbate the disease pathology. However, monocytes differ in susceptibilities to influenza virus infection. Herein, susceptibilities of U937 and THP-1 monocytic cells to PR8 virus infection, the associated cellular factor- sialic acid (SA) receptor distribution and viral factor were determined. Moreover, amino acid sequences in hemagglutinin (HA) receptor binding domain (RBD) of PR8 virus that determine SA preferences were analysed. PR8 infected U937 cells express significantly higher numbers of nucleoprotein positive cells suggesting U937 cells being more susceptible to influenza virus than THP-1 cells. Lectin staining suggested similar pattern of SA receptor distribution in both cells. Interestingly, sequence analysis of RBD suggested their preferences for alpha 2,3 SA receptors suggesting RBD sequences are not always determining for SA preferences. Furthermore, the resistance barrier on THP-1 cells was overcome by H5N1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.