Evidence map›Paper›PMID 30538988›Full record

ArticleFrontiers in medicine2018

Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease Phenotype.

Eugene Gonzalez-Lopez, Yuka Imamura Kawasawa, Vonn Walter, Lijun Zhang, Walter A Koltun, Xuemei Huang, Kent E Vrana, Matthew D Coates

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022
    Pooled it
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  3. Applications of artificial intelligence in drug discovery for neurological diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  4. Review
  5. Structural basis of inhibition of human NaNature communications · 2025
    Article
  6. Article
  7. Article
  8. Structural basis of inhibition of human NabioRxiv : the preprint server for biology · 2024
    Article
  9. Heterologous expression of the human wild-type and variant NaNeurogastroenterology and motility · 2024
    Article
  10. Review
  11. Lifestyle Factors and Silent Inflammatory Bowel Disease.Inflammatory intestinal diseases · 2023
    Article
  12. Peripheral temperature dysregulation associated with functionally altered NaPflugers Archiv : European journal of physiology · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Silent Inflammatory Bowel Disease.Crohn's & colitis 360 · 2021
    Review
  17. Review
  18. Article
  19. Impact of the NaJournal of neurophysiology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eugene Gonzalez-LopezDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, United States.
Yuka Imamura KawasawaDepartments of Pharmacology and Biochemistry & Molecular Biology, Institute for Personalized Medicine, Penn State College of Medicine, Hershey, PA, United States.
Vonn WalterDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, United States.
Lijun ZhangDepartment of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA, United States.
Walter A KoltunDivision of Colorectal Surgery, Department of Surgery, Penn State College of Medicine, Hershey, PA, United States.
Xuemei HuangDepartment of Neurology, Penn State College of Medicine, Hershey, PA, United States.
Kent E VranaDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, United States.
Matthew D CoatesDivision of Gastroenterology & Hepatology, Department of Medicine, Penn State College of Medicine, Hershey, PA, United States.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

abdominal paingenetic polymorphismhypoalgesiainflammatory bowel diseaseNav1.8SCN10Avoltage-gated sodium channels

Identifiers

PMID30538988
PMCPMC6277464
OpenAlexW2903280842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.