Evidence map›Paper›PMID 30538887›Full record

ArticleJournal of radiosurgery and SBRT2018

Linac-based fractionated stereotactic radiosurgery for high-risk meningioma.

Rahul N Prasad, John C Breneman, Timothy Struve, Ronald E Warnick, Luke E Pater

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of radiosurgery and SBRT, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rahul N PrasadDepartment of Radiation Oncology at the University of Cincinnati Barrett Cancer Center, 234 Goodman Street, Cincinnati, OH 45219, USA.
John C BrenemanDepartment of Radiation Oncology at the University of Cincinnati Barrett Cancer Center, 234 Goodman Street, Cincinnati, OH 45219, USA.
Timothy StruveDepartment of Radiation Oncology at the University of Cincinnati Barrett Cancer Center, 234 Goodman Street, Cincinnati, OH 45219, USA.
Ronald E WarnickMayfield Clinic, 3825 Edwards Road, Suite 300, Cincinnati, OH 45209, USA.
Luke E PaterDepartment of Radiation Oncology at the University of Cincinnati Barrett Cancer Center, 234 Goodman Street, Cincinnati, OH 45219, USA.
University of Cincinnati · USMayfield Brain & Spine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSingle-fraction stereotactic radiosurgery(SRS) for meningioma has high rates of symptomatic perilesional edema in some settings. Fractionated stereotactic radiosurgery(fSRS) could decrease edema rates while maintaining tumor control. METHODS AND MATERIALS: Patients at an institution were retrospectively reviewed(2013-2017). Adults receiving definitive, linear accelerator(linac)-based fSRS (25-30Gy/5 fractions) were included. fSRS was recommended for tumors at high risk for perilesional edema with SRS due to large size, prior irradiation, or proximity to organs at risk. Endpoints included rates of symptomatic, radiographically-defined perilesional edema and local control(LC).

results12 Patients with 13 meningiomas met criteria. 24-month actuarial LC and overall survival were 87% and 100%. Symptomatic, post-treatment edema was identified on follow-up MRI in 31% of cases. No variables predicted edema, but affected lesions were larger(6.82 v. 2.46cc).

conclusionLinac-based fSRS for meningioma has high local control and modest toxicity rates similar to SRS in the literature. Prospective studies comparing fSRS/SRS are warranted.

Indexed as

fractionated stereotactic radiosurgerylinear accelerated-basedlocal controlmeningiomaperilesional edema

Identifiers

PMID30538887
PMCPMC6255720
OpenAlexW2997293863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.