Evidence map›Paper›PMID 30538835›Full record

ArticleCurrent health sciences journal

NOD2 Arg702Trp Polymorphism in Romanian Patients with Gastric Cancer.

D N Florescu, D R Tudoraşcu, F Burada, M G Cucu, M E Ciurea

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Article in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

D N FlorescuResearch Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania.
D R TudoraşcuInternal Medicine II, University of Medicine and Pharmacy of Craiova, Romania.
F BuradaDepartment of Medical Genetics, University of Medicine and Pharmacy Craiova, Romania.
M G CucuHuman Genomics Laboratory, University of Medicine and Pharmacy of Craiova, Romania.
M E CiureaPlastic and Reconstructive Surgery, University of Medicine and Pharmacy of Craiova, Romania.
University of Medicine and Pharmacy of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur study aimed to assess a possible correlation between NOD2 Arg702Trp (rs2066844) polymorphism and gastric cancer risk in a Romanian population. MATERIAL/

methodsA total of 322 subjects (72 patients with gastric adenocarcinoma and 250 healthy controls) were included. Genomic DNA was extracted from blood leukocytes and NOD2 Arg702Trp polymorphism was genotyped by Real-Time PCR using specific TaqMan probes.

resultsNo statistically significant difference was observed between gastric cancer patients and controls when we compared one genotype with other genotype (the CC genotype serves as reference) (OR 0.45, 95% CI: 0.10 - 2.05) or when we compared allele frequencies (the C allele serves as reference) (OR 0.46, 95% CI: 0.11 - 2.04). We examined separately the association of this polymorphism with tumor site and histologic type and no correlation was found.

conclusionNOD2 Arg702Trp polymorphism is not associated with gastric cancer risk and further investigations are needed to elucidate the contribution of NOD2 gene in gastric carcinogenesis.

Indexed as

gastric cancergenegenotypeNOD2 polymorphism

Identifiers

PMID30538835
PMCPMC6243512
OpenAlexW3022886306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.