Evidence map›Paper›PMID 30538832›Full record

ArticleCurrent health sciences journal

Endomicroscopy with Fluorescent CD105 Antibodies for "In Vivo" Imaging of Colorectal Cancer Angiogenesis.

A Ciocâlteu, D Pirici, A Stefanescu, C V Georgescu, V Şurlin, A Săftoiu

Abstract read
In one paragraph

Article in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. CD105: tumor diagnosis, prognostic marker and future tumor therapeutic target.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

A CiocâlteuResearch Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania.
D PiriciDepartment of Research Methodology, University of Medicine and Pharmacy of Craiova, Romania.
A StefanescuDepartment of Research Methodology, University of Medicine and Pharmacy of Craiova, Romania.
C V GeorgescuDepartment of Pathology, Emergency County Hospital, Craiova, Romania.
V ŞurlinDepartment of Surgery, University of Medicine and Pharmacy of Craiova, Romania.
A SăftoiuResearch Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania.
University of Medicine and Pharmacy of Craiova · ROCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this case report was to evaluate the feasibility of in vivo acquisition of microscopic images using fluorescent CD105 antibodies for molecular imaging in human colorectal cancer. After excluding the presence of tissue autofluorescence, the antibody solution was topically administered through a spray-catheter. The targeted area was analyzed by eCLE and images were recorded. The fractal dimension of tumor vessels and the vessel density were determined using ImageJ software. Immunohistochemistry was used as a gold standard. In vivo CLE analysis of CD105 expression enabled the study of tumor vascular network, revealing a chaotic structure.

Indexed as

CD105-FITCcolorectal cancerconfocal laser endomicroscopy (CLE)in vivo endoscopic imagingneoangiogenesis

Identifiers

PMID30538832
PMCPMC6246985
OpenAlexW3023717664

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.