Evidence map›Paper›PMID 30538823›Full record

ArticleVirus evolution2018

Maintenance and reappearance of extremely divergent intra-host HIV-1 variants.

Joel O Wertheim, Alexandra M Oster, Ben Murrell, Neeraja Saduvala, Walid Heneine, William M Switzer, Jeffrey A Johnson

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Joel O WertheimDepartment of Medicine, University of California, San Diego, USA.
Alexandra M OsterDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, USA.
Ben MurrellDepartment of Medicine, University of California, San Diego, USA.
Neeraja SaduvalaICF International, Atlanta, USA.
Walid HeneineDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, USA.
William M SwitzerDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, USA.
Jeffrey A JohnsonDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, USA.
Centers for Disease Control and Prevention · USUniversity of California, San Diego · USICF International (United States) · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SONIA JAIN · 1994 to 2026
$78.4M
Automation and Evaluation of Real-Time Transmission Network-Based HIV Prevention Services in New York CityR01AI135992 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2018 to 2022
$3.6M
Public Health Implications of HIV Transmission NetworksK01AI110181 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2014 to 2018
$668k
Viral sequence and dynamic determinants of antibody breadthR00AI120851 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRELL, BENJAMIN SYLVESTER · 2016 to 2017
$493k
Viral sequence and dynamic determinants of antibody breadthK99AI120851 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRELL, BENJAMIN SYLVESTER · 2015 to 2015
$124k
NIAID NIH HHS K01 AI110181NIAID NIH HHS K99 AI120851NIAID NIH HHS P30 AI036214NIAID NIH HHS R00 AI120851NIAID NIH HHS R01 AI135992
6 · The paper itself

Abstract

Understanding genetic variation in human immunodeficiency virus (HIV) is clinically and immunologically important for patient treatment and vaccine development. We investigated the longitudinal intra-host genetic variation of HIV in over 3,000 individuals in the US National HIV Surveillance System with at least four reported HIV-1 polymerase (

Indexed as

genetic variationHIVmolecular evolutionsuperinfection

Identifiers

PMID30538823
PMCPMC6279948
OpenAlexW2903176674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.