Evidence map›Paper›PMID 30538751›Full record

ArticleStem cells international2018

Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats.

Yongting Zhang, Yuwen Li, Wenting Li, Jie Cai, Ming Yue, Longfeng Jiang, Ruirui Xu, Lili Zhang, Jun Li, Chuanlong Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Effects of SRWFood & nutrition research · 2026
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  6. Review
  7. NINJ1 impairs the anti-inflammatory function of hUC-MSCs with synergistic IFN-γ and TNF-α stimulation.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yongting ZhangDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yuwen LiDepartment of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Wenting LiThird Liver Unit, Department of Infectious Disease, The First Affiliated Hospital of Science and Technology of China, Hefei 230001, China.ORCID 0000-0001-7734-4838
Jie CaiDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Ming YueDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Longfeng JiangDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Ruirui XuDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Lili ZhangDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jun LiDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID 0000-0002-1961-7188
Chuanlong ZhuDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID 0000-0002-0657-828X
Jiangsu Province Hospital · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have described beneficial effects of an infusion of mesenchymal stem cells (MSCs) derived from Wharton's jelly tissue, for the treatment of acute liver failure (ALF). However, data on the therapeutic potential of culture-expanded MSCs are lacking. We examined the therapeutic potential of passage five (P5) and ten (P10) human umbilical cord- (hUC-) MSCs via their transplantation into Sprague-Dawley (SD) rats with D-galactosamine (D-GalN) and LPS-induced acute liver failure (ALF). SD rats were randomly divided into three groups: control group, P5 hUC-MSCs group, and P10 hUC-MSCs group. After transplantation, P5 hUC-MSCs provided a significant survival benefit. The analysis of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) levels showed that transplantation with P5 hUC-MSCs was more effective than treatment with P10 hUC-MSCs. P5 hUC-MSCs also successfully downregulated the hepatic activity index (HAI) scores. Compared to P10 hUC-MSCs

Identifiers

PMID30538751
PMCPMC6261392
OpenAlexW2901801889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.