Evidence map›Paper›PMID 30538697›Full record

ReviewFrontiers in immunology2018

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.

Camille Khairallah, Timothy H Chu, Brian S Sheridan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Guardians within: Cross-talk between the gut microbiome and host immune system.World journal of gastrointestinal pathophysiology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Immunological insights into hypertension: unraveling triggers and potential therapeutic avenues.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  17. Article
  18. Characteristics of splenic PD-1Immunologic research · 2024
    Article
  19. Article
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Camille KhairallahDepartment of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, NY, United States.
Timothy H ChuDepartment of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, NY, United States.
Brian S SheridanDepartment of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, NY, United States.
Stony Brook University · US

Funding

T Cell Response to Listeria Monocytogenes InfectionR01AI076457 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SHERIDAN, BRIAN S · 2009 to 2019
$3.8M
Enhanced adaptive gamma delta T cell immunity in aged miceR21AG058981 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI SHERIDAN, BRIAN S · 2018 to 2019
$432k
Mechanisms regulating intestinal resident memory CD8 T cell developmentR21AI137929 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI SHERIDAN, BRIAN S · 2018 to 2019
$432k
NIAID NIH HHS R01 AI076457NIAID NIH HHS R21 AI137929NIA NIH HHS R21 AG058981
6 · The paper itself

Abstract

Epithelial and mucosal barriers are critical interfaces physically separating the body from the outside environment and are the tissues most exposed to microorganisms and potential inflammatory agents. The integrity of these tissues requires fine tuning of the local immune system to enable the efficient elimination of invasive pathogens while simultaneously preserving a beneficial relationship with commensal organisms and preventing autoimmunity. Although they only represent a small fraction of circulating and lymphoid T cells, γδ T cells form a substantial population at barrier sites and even outnumber conventional αβ T cells in some tissues. After their egress from the thymus, several γδ T cell subsets naturally establish residency in predetermined mucosal and epithelial locations, as exemplified by the restricted location of murine Vγ5

Indexed as

AnimalsHomeostasisHumansImmunologic MemoryInflammationIntestinal MucosaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, gamma-deltaadaptive γδ T cellsbarrier infectionsinnate γδ T cellsmemory γδ T cellsresident γδ T cells

Identifiers

PMID30538697
PMCPMC6277633
OpenAlexW2902943177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.