ArticleFrontiers in neurology2018
The Method of Silent Substitution for Examining Melanopsin Contributions to Pupil Control.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05483296 (Modulating Evening Responses to Light by Afternoon Light Exposure in Adolescents), which is not on this map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulating Evening Responses to Light by Afternoon Light Exposure in Adolescents
Who cites it
44 citing papers in PubMed, 97 citations in OpenAlex.
- Melatonin suppression does not automatically alter sleepiness, vigilance, sensory processing, or sleep.Sleep · 2022Trial
- Trial
- Simulated and natural changes in intraocular transparency selectively affect photoreceptor-specific pupil responses.Scientific reports · 2026Article
- Simulated natural daylight and twilight modulate activity and light sampling behaviour in mice.BMC biology · 2026Article
- Binocular combination in the autonomic nervous system.PloS one · 2026Article
- A method for setting the melanopsin and rhodopsin content in commercial LED sources to investigate the effects of ambient light on behavior.Behavior research methods · 2025Article
- Light of both high and low melanopic illuminance improves alertness and attention during daytime.Scientific reports · 2025Article
- Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.iScience · 2025Article
- Afternoon to early evening bright light exposure reduces later melatonin production in adolescents.Npj biological timing and sleep · 2025Article
- Within-subjects ultra-short sleep-wake protocol for characterising circadian variations in retinal function.PloS one · 2025Article
- Frequency tagged multifocal pupillary response fields identify age-related macular degeneration and diabetic retinopathy.Frontiers in neuroscience · 2025Article
- Pupil responses to melanopsin-isolating stimuli as a potential diagnostic biomarker for glaucoma.PloS one · 2025Article
- Selecting, implementing and evaluating control and placebo conditions in light therapy and light-based interventions.Annals of medicine · 2024Review
- Development of an Innovative Pupillometer Able to Selectively Stimulate the Eye's Fundus Photoreceptor Cells.Diagnostics (Basel, Switzerland) · 2024Article
- The Impact of Pupil Constriction on the Relationship Between Melanopic EDI and Melatonin Suppression in Young Adult Males.Journal of biological rhythms · 2024Article
- Regulation of pupil size in natural vision across the human lifespan.Royal Society open science · 2024Article
- Temporal Sensitivity for Achromatic and Chromatic Flicker across the Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The cognitive impact of light: illuminating ipRGC circuit mechanisms.Nature reviews. Neuroscience · 2024Review
- Temporal sensitivity for achromatic and chromatic flicker across the visual cortex.bioRxiv : the preprint server for biology · 2024Article
- Seasonal Variation in the Responsiveness of the Melanopsin System to Evening Light: Why We Should Report Season When Collecting Data in Human Sleep and Circadian Studies.Clocks & sleep · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The human pupillary light response is driven by all classes of photoreceptors in the human eye-the three classes of cones, the rods, and the intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. These photoreceptor classes have distinct but overlapping spectral tuning, and even a monochromatic light with a wavelength matched to the peak spectral sensitivity of a given photoreceptor will stimulate all photoreceptors. The method of silent substitution uses pairs of lights ("metamers") to selectively stimulate a given class of photoreceptors while keeping the activation of all others constant. In this primer, we describe the method of silent substitution and provide an overview of studies that have used it to examine inputs to the human pupillary light response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.