Evidence map›Paper›PMID 30538626›Full record

ArticleFrontiers in human neuroscience2018

Functional and Structural Brain Plasticity in Adult Onset Single-Sided Deafness.

Yingying Shang, Leighton B Hinkley, Chang Cai, Karuna Subramaniam, Yi-Shin Chang, Julia P Owen, Coleman Garrett, Danielle Mizuiri, Pratik Mukherjee, Srikantan S Nagarajan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yingying ShangDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.
Leighton B HinkleyDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Chang CaiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Karuna SubramaniamDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, United States.
Yi-Shin ChangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Julia P OwenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Coleman GarrettDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Danielle MizuiriDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Pratik MukherjeeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Srikantan S NagarajanDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.
Steven W CheungDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-sided deafness (SSD) or profound unilateral hearing loss obligates the only serviceable ear to capture all acoustic information. This loss of binaural function taxes cognitive resources for accurate listening performance, especially under adverse environments or challenging tasks. We hypothesized that adults with SSD would manifest both functional and structural brain plasticity compared to controls with normal binaural hearing. We evaluated functional alterations using magnetoencephalographic imaging (MEGI) of brain activation during performance of a moderately difficult auditory syllable sequence reproduction task and assessed structural integrity using diffusion tensor imaging (DTI). MEGI showed the SSD cohort to have increased induced oscillations in the theta band over the left superior temporal cortex and decreased induced gamma band oscillations over the frontal and parietal cortices between 175 and 475 ms following stimulus onset. DTI showed the SSD cohort to have extensive fractional anisotropy (FA) reduction in both auditory and non-auditory tracts and regions. Overlaying functional and structural changes revealed by the two imaging techniques demonstrated close registration of cortical areas and white matter tracts that expressed brain plasticity. Hence, complete loss of input from one ear in adulthood triggers both functional and structural alterations to dorsal temporal and frontal-parietal areas.

Indexed as

auditory memorydiffusion tensor imagingmagnetoencephalographyplasticitysingle-sided deafness

Identifiers

PMID30538626
PMCPMC6277679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.