ArticleGut1978
Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease.
Article in Gut, 1978. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Decreased expression of PTH1R is a poor prognosis in hepatocellular carcinoma.Cancer biomarkers : section A of Disease markers · 2018Pooled it
- Glucocorticosteroids for primary sclerosing cholangitis.The Cochrane database of systematic reviews · 2010Pooled it
- Clinical practice guidelines for the diagnosis and management of osteoporosis. Scientific Advisory Board, Osteoporosis Society of Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1996Guideline
- Outcomes of patients with post-hepatectomy hypophosphatemia: A narrative review.World journal of hepatology · 2022Review
- Diagnosis and Management of Cirrhosis-Related Osteoporosis.BioMed research international · 2016Review
- Anti-inflammatory effects of bamboo salt and sodium fluoride in human gingival fibroblasts--An in vitro study.The Kaohsiung journal of medical sciences · 2015Article
- Bamboo salt attenuates CCl4-induced hepatic damage in Sprague-Dawley rats.Nutrition research and practice · 2013Article
- Vitamin D and bone disease.BioMed research international · 2013Review
- Iron homeostasis in osteoporosis and its clinical implications.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Review
- Vitamin D nutrition and bone disease in adults.Reviews in endocrine & metabolic disorders · 2001Review
- Osteodystrophy in patients with chronic hepatitis and liver cirrhosis.Journal of gastroenterology · 1996Article
- Amount and composition of bone minerals in chronic liver disease.Digestive diseases and sciences · 1996Article
- Osteopenia in primary biliary cirrhosis and cirrhosis of the liver in women, evaluated by dual-energy X-ray absorptiometry.Journal of gastroenterology · 1994Article
- Article
- Review
- Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels.The Journal of clinical investigation · 1986Article
- Osteomalacia--a clinical review of 46 cases.Irish journal of medical science · 1985Article
- Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease.The Journal of clinical investigation · 1984Article
- Effects of iron overload on bone remodeling in pigs.The American journal of pathology · 1984Article
- Vitamin D deficiency, osteomalacia, and primary biliary cirrhosis. Response to orally administered vitamin D3.Digestive diseases and sciences · 1983Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty of 32 patients with either chronic cholestatic or hepatocellular liver disease had bone pain or recent fractures. On bone biopsy five patients had normal bone, 15 had osteomalacia, five had osteoporosis, and seven had a combination of osteomalacia and osteoporosis. In the presence of osteoporosis, osteomalacia was minimal or absent. There was no biochemical, radiological, or histological evidence of excess parathyroid activity. No significant correlations were demonstrated between the plasma and urinary biochemical findings and the presence of either osteoporosis or osteomalacia and bone biopsy was essential for correct diagnosis. There was no statistical relationship between low serum 25-hydroxy vitamin D values and the presence of osteomalacia. Bone disease was not prevented by regular intramuscular vitamin D2, although biochemical changes were improved. Drugs such as corticosteroids and cholestyramine may be important aetiological factors in hepatic osteodystrophy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.