Evidence map›Paper›PMID 30538572›Full record

ArticleCancer management and research2018

Association study of genetic variation of lncRNA MALAT1 with carcinogenesis of colorectal cancer.

Kexin Zhao, Si Jin, Bo Wei, Shiqiong Cao, Zhifan Xiong

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. The Relationship betweenMedicina (Kaunas, Lithuania) · 2022
    Pooled it
  2. Meta-analysis of the association betweenThe Journal of international medical research · 2020
    Pooled it
  3. Article
  4. International journal of general medicine · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Regulatory Networks of LncRNA MALAT-1 in Cancer.Cancer management and research · 2020
    Review
  12. Genetic Variants of lncRNAJournal of clinical medicine · 2019
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kexin ZhaoDivision of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, People's Republic of China, xiongzhifan@aliyun.com.
Si JinDepartment of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430077, People's Republic of China.
Bo WeiDepartment of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430077, People's Republic of China.
Shiqiong CaoDivision of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, People's Republic of China, xiongzhifan@aliyun.com.
Zhifan XiongDivision of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, People's Republic of China, xiongzhifan@aliyun.com.
Huazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionColorectal cancer (CRC) remains a major public health concern worldwide. However, the detailed molecular mechanisms of CRC remain poorly understood.

methodsIn the current study, we evaluated associations of four genetic variants located in the promoter and gene region of long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with CRC susceptibility among a Chinese population with 966 CRC cases and 988 healthy controls, using a two-stage, case-control study design (400 CRC cases and 400 controls in stage 1, and 566 CRC cases and 588 controls in stage 2).

resultsWe found that the minor alleles of rs619586 (OR=0.73; 95% CI=0.60-0.88;

conclusionTaken together, our findings provided strong evidence for the hypothesis that genetic variants in lncRNA MALAT1 might contribute to the carcinogenesis of CRC.

Indexed as

colorectal cancergeneticlncRNAMALAT1susceptibility

Identifiers

PMID30538572
PMCPMC6260139
OpenAlexW2901748966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.