Evidence map›Paper›PMID 30538565›Full record

ArticleCancer management and research2018

miRNA-299-5p regulates estrogen receptor alpha and inhibits migration and invasion of papillary thyroid cancer cell.

Zhihong Wang, Liang He, Wei Sun, Yuan Qin, Wenwu Dong, Ting Zhang, Ping Zhang, Hao Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhihong WangDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
Liang HeDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
Wei SunDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
Yuan QinDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
Wenwu DongDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
Ting ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
Ping ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
Hao ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China, haozhang@cmu.edu.cn.
First Hospital of China Medical University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of papillary thyroid cancer (PTC) is increasing faster than any other solid tumors worldwide. Invasion and metastasis are the main reasons for the poor prognosis of patients with PTC. Previously, we observed significantly low expression of miRNA-299-5p in invasive PTC tissue samples.

aimThe present study aimed to determine whether miR-299-5p plays a key role in PTC migration and invasion. MATERIALS AND

methodsThe miR-299-5p expression level was measured using quantitative real-time PCR in 109 human PTC samples and paired adjacent normal tissues and in the human BCPAP PTC cell line. The effects of miR-299-5p on PTC cell migration and invasion were assessed using wound healing and transwell assays. In addition, we searched for the miR-299-5p target, and the potential mechanism was demonstrated using a reporter assay and rescue experiment.

resultsThe expression of miR-299-5p was associated with gender and extrathyroidal extension, and an elevated level of miR-299-5p suppressed BCPAP cell migration and invasion. Estrogen receptor α (ERα) is a direct target of miR-299-5p. The expression level of ERα was significantly higher in PTC tissues and was associated with migration and invasion in PTC cells. Overexpression of ERα could impair miR-299-5p-induced inhibition of migration and invasion. As a key factor of the pathway related to PTC invasion, Gli1 can be combined with ERα and can be regulated by miR-299-5p.

conclusionOur data suggested that miR-299-5p could participate in PTC migration and invasion and could be a potential therapeutic target for patients with aggressive PTC tumors.

Indexed as

ERαestrogen receptor αinvasionmigrationmiR-299-5ppapillary thyroid cancerPTC

Identifiers

PMID30538565
PMCPMC6257197
OpenAlexW2901656555

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.