Evidence map›Paper›PMID 30538481›Full record

ArticleNeuropsychiatric disease and treatment2018

Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder.

Pengfei Cao, Jun Xing, Yin Cao, Qi Cheng, Xiaojing Sun, Qi Kang, Libin Dai, Xianju Zhou, Zixiang Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pengfei CaoPsychological Centre for Adolescents and Children, The Affiliated 102 Hospital of The Second Military Medical University of People's Liberation Army of China, Shanghai, China, axiang952@sohu.com.
Jun XingPsychological Centre for Adolescents and Children, The Affiliated 102 Hospital of The Second Military Medical University of People's Liberation Army of China, Shanghai, China, axiang952@sohu.com.
Yin CaoLaboratory of Neurological Diseases, Department of Neurology, The Affiliated Changzhou No 2 People's Hospital of Nanjing Medical University, Changzhou, China, xianju_zhou@yahoo.com.
Qi ChengPsychological Centre for Adolescents and Children, The Affiliated 102 Hospital of The Second Military Medical University of People's Liberation Army of China, Shanghai, China, axiang952@sohu.com.
Xiaojing SunPsychological Centre for Adolescents and Children, The Affiliated 102 Hospital of The Second Military Medical University of People's Liberation Army of China, Shanghai, China, axiang952@sohu.com.
Qi KangPsychological Centre for Adolescents and Children, The Affiliated 102 Hospital of The Second Military Medical University of People's Liberation Army of China, Shanghai, China, axiang952@sohu.com.
Libin DaiPsychological Centre for Adolescents and Children, The Affiliated 102 Hospital of The Second Military Medical University of People's Liberation Army of China, Shanghai, China, axiang952@sohu.com.
Xianju ZhouLaboratory of Neurological Diseases, Department of Neurology, The Affiliated Changzhou No 2 People's Hospital of Nanjing Medical University, Changzhou, China, xianju_zhou@yahoo.com.
Zixiang SongPsychological Centre for Adolescents and Children, The Affiliated 102 Hospital of The Second Military Medical University of People's Liberation Army of China, Shanghai, China, axiang952@sohu.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the effect of repetitive transcranial magnetic stimulation (rTMS) combined with atomoxetine (ATX) in the treatment of attention-deficit hyperactivity disorder (ADHD).

methodsSixty-four patients with newly diagnosed ADHD were enrolled from January 2016 to October 2017 from Psychological Centre for Adolescents and Children at 102th Hospital of People's Liberation Army of China. These patients were randomly assigned to three groups according to treatment method: the rTMS group, the ATX group, and the rTMS+ ATX group. Before treatment and 6 weeks after treatment, clinical symptoms and executive functions of ADHD patients were evaluated with the Swanson, Nolan, and Pelham, Version IV (SNAP-IV) Questionnaire, continuous performance test, three subtests (arithmetic, digit span, and coding) of Wechsler Intelligence Scale for Children, as well as Iowa Gambling Tasks (IGT). The effects of treatment were compared among three groups.

resultsAfter 6 weeks of treatment, the scores of all factors in the SNAP-IV questionnaire were lower than those before treatment in the three groups; the scores of three subtests of Wechsler Intelligence Scale for Children, continuous performance test, and IGT were also significantly higher than those before treatment. The rTMS+ ATX group had a better improvement in attention deficits and hyperactivity impulse on the SNAP-IV questionnaire compared with the other groups, and also had a higher efficacy on cold and hot executive functions such as arithmetic, forward numbers, coding, and IGT. In addition, the ATX group performed better than the rTMS group in coding and IGT.

conclusionrTMS, ATX, and the combination therapy are effective in improving core symptoms and executive function in patients with ADHD. The combined treatment has significant therapeutic advantages over the single treatment groups. Compared with rTMS, the drug therapy has a better improvement in coding and IGT.

Indexed as

atomoxetineattention-deficit hyperactivity disorderexecutive functionrepetitive transcranial magnetic stimulation

Identifiers

PMID30538481
PMCPMC6263241

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.